Results 61 to 70 of about 848 (155)

1282. Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In vitro Activity Against Members of the Fusarium oxysporum and Fusarium solani Species Complexes [PDF]

Open Forum Infectious Diseases, 2020
Abstract Background Invasive fusariosis is associated with marked morbidity and mortality in immunocompromised hosts, and treatment options are limited. Common etiologic agents include members of the F. oxysporum and F. solani species complexes (FOSC and FSSC, respectively).
Badali, Hamid, Patterson, Hoja, Sanders, Carmita, Mermella, Barbara, Gibas, Connie, Mele, James, Fan, Hongxin, Ibrahim, Ashraf S, Shaw, Karen J, Wiederhold, Nathan P   +9 more
openaire   +1 more source

1954. In vivo Efficacy of Delayed Therapy with the Novel Inositol Acyltransferase Inhibitor Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis [PDF]

Open Forum Infectious Diseases, 2019
Abstract Background Candida auris is an emerging pathogen associated with antifungal resistance and high mortality. The novel antifungal manogepix (APX001A) prevents glycosylphosphatidylinositol-anchored protein maturation through inhibition of the inositol acyltransferase Gwt1 enzyme, and has ...
Wiederhold, Nathan P, Najvar, Laura K, Shaw, Karen J, Jaramillo, Rosie, Patterson, Hoja P, Olivo, Marcos, Catano, Gabriel, Patterson, Thomas F   +7 more
openaire   +1 more source

Successful Use of Fosmanogepix for Treatment of Rare Highly Resistant Cutaneous Fusariosis in a Pediatric Patient With STAT3 Hyper-Immunoglobulin E Syndrome and End-Stage Kidney Disease

Open Forum Infectious Diseases, 2023
We describe the successful use of the novel antifungal drug fosmanogepix to treat a chronic case of multidrug-resistant cutaneous Fusarium suttonianum infection in a pediatric patient with STAT3 hyper-IgE syndrome and end-stage kidney disease on peritoneal dialysis.
Kathryn P Goggin, Jackson Londeree, Alexandra F Freeman, Rouba Garro, Roshan P George   +4 more
openaire   +2 more sources

Neurovascular Complications of Iatrogenic Fusarium solani Meningitis [PDF]

A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial
Barreto, Andrew, Campo Maldonado, Jose, Hassan, Ameer E., McCullough, Louise, Meeks, Grant, Parada, Victoria, Sheth, Sunil A., Strong, Nora, Tan, Chunfeng, Villalba, Julian A.   +9 more
core   +2 more sources

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

840 Limb Salvage After Lomentospora Osteomyelitis in a Burn-Injured Patient Treated with Fosmanogepix [PDF]

J Burn Care Res
Abstract Introduction Burn patients are highly susceptible to infections due to factors like loss of the protective skin barrier, immunosuppression, prolonged open wounds, mechanical ventilation and invasive lines.
Sani, Gelina, Powelson, Ian, Bays, Derek, Young, Sierra, Louie, Erin, Heard, Jason   +5 more
europepmc   +2 more sources

The combination of manogepix and itraconazole is synergistic and inhibits the growth of Madurella mycetomatis in vitro but not in vivo [PDF]

, 2023
Mycetoma is a neglected tropical disease commonly caused by the fungus Madurella mycetomatis. Standard treatment consists of extensive treatment with itraconazole in combination with surgical excision of the infected tissue, but has a low success rate ...
Eadie, Kimberly, Fahal, Ahmed H., Konings, Mickey, Nyuykonge, Bertrand, Strepis, Nikolaos, van de Sande, Wendy W.J., Verbon, Annelies   +6 more
core  

Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp. [PDF]

, 2023
With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus ...
Ackermann, Katharina, Cornely, Oliver Andreas, Koehler, Philipp, Lass-Flörl, Cornelia, Rath, Peter-Michael, Simon, Michaela, Steinmann, Jörg, Stemler, Jannik, Többen, Christina   +8 more
core   +1 more source

Analysis of Susceptibility and Drug Resistance of Antifungal Agents in Aspergillosis and Mucormycosis Patients: A Systematic Review

Mycoses, Volume 68, Issue 10, October 2025.
ABSTRACT Objectives To evaluate the susceptibility and resistance of Aspergillus and Mucorales isolates to antifungal agents. Methods Studies in susceptibility or resistance of Aspergillus and Mucorales isolates to antifungal agents published between January 2010 and June 2023 were systematically searched in PubMed, EMBASE and the Cochrane Library. The
Yinggai Song, Paul E. Verweij, Jochem B. Buil, Sybren de Hoog, Jie Liu, Jiaxian Guo, Wei Liu, Ruoyu Li   +7 more
wiley   +1 more source

Breakthrough Invasive Mould Infections Under Posaconazole Prophylaxis in Patients With Haematologic Malignancies: A Case–Control Study

Mycoses, Volume 68, Issue 10, October 2025.
ABSTRACT Background Posaconazole (POS) prophylaxis is recommended for the prevention of invasive mould infections among patients with haematologic cancer and prolonged neutropenia or following allogeneic haematopoietic cell transplantation. Albeit rare, breakthrough invasive mould infections (bIMI) are associated with high mortality rates.
Camille Marchetti, Emmanouil Glampedakis, Jannik Stemler, Luise Hänsel, Sabine Kuster, Ilona Kronig, Katia Boggian, Nina Khanna, Dionysios Neofytos, Oliver A. Cornely, Frederic Lamoth, for the Fungal Infection Network of Switzerland (FUNGINOS), Werner Albrich, Christoph Berger, Anne Bergeron, Sabina Berezowska, Pierre‐Yves Bochud, Katia Boggian, Anna Conen, Stéphane Emonet, Véronique Erard, Christian Garzoni, Daniel Goldenberger, Vladimira Hinic, Cedric Hirzel, Nina Khanna, Malte Kohns, Andreas Kronenberg, Frederic Lamoth, Basile Landis, Oscar Marchetti, Konrad Mühlethaler, Linda Müller, Dionysios Neofytos, Michael Osthoff, Jean‐Luc Pagani, Chantal Quiblier, Ilana Reinhold, Arnaud Riat, Niels Rupp, Dominique Sanglard, Peter Werner Schreiber, Martin Siegemund, Laura Walti   +43 more
wiley   +1 more source