Results 71 to 80 of about 848 (155)

Fungal lung disease. [PDF]

Fungal lung disease encompasses a wide spectrum of organisms and associated clinical conditions, presenting a significant global health challenge. The type and severity of disease are determined by underlying host immunity and infecting fungal strain ...
Agarwal, Ritesh, Chotirmall, Sanjay, Delhaes, Laurence, Hage, Chadi, Jaggi, Tavleen, Langelier, Charles, Lydon, Emily, Shah, Anand, Tiew, Pei, Waterer, Grant   +9 more
core   +1 more source

Lactams Exhibit Potent Antifungal Activity Against Monospecies and Multispecies Interkingdom Biofilms on a Novel Hydrogel Skin Model

APMIS, Volume 133, Issue 1, January 2025.
ABSTRACT Infections of intact and damaged skin barriers and keratin are frequently associated with complex biofilm communities containing bacteria and fungi, yet there are limited options for successful management. This study intended to focus on the utility of some novel proprietary lactam molecules, quorum sensing (QS)–derived halogenated furanones ...
Hafsa Abduljalil, Om Alkhir Alshanta, Safa Chougule, Mark Butcher, Bryn Short, William McLean, Neil Parry, Joanne O'Keeffe, Gordon Ramage   +8 more
wiley   +1 more source

FUNGAL INFECTIONS ASSOCIATED WITH COVID-19 [PDF]

, 2021
To study fungal infections such as Mucormycosis, Aspergillosis, Candidiasis, Cryptococcosis associated with Covid-19. A detailed study was done with the information gathered from the articles in specified databases, online sources, and online published ...
AGARWAL, RICHA, ASIJA, RAJESH, SHARMA, ANTA, TANWAR, SONIKA   +3 more
core   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity

Macromolecular Bioscience, Volume 24, Issue 5, May 2024.
Synthetic polymers inspired by natural antimicrobial peptides have shown promise for the treatment of fungal infections. The present study compares linear to star‐like topology of amphiphilic, positively charged polymers. A low‐Xn 3‐arm polymer shows favourable activity against Candida spp. and biocompatibility with fibroblasts.
Sebastian Schaefer, Daniele Melodia, Nathaniel Corrigan, Megan Denise Lenardon, Cyrille Boyer   +4 more
wiley   +1 more source

What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Volume 13, Issue 2, April 2024.
Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley   +1 more source

Multidrug resistance mechanisms and therapeutic strategies in Candida auris [PDF]

In recent years, Candida auris has emerged as a formidable global health threat due to its multidrug resistance, high transmissibility in healthcare settings, and diagnostic challenges. Unlike most Candida species, C. auris can colonize the skin, persist
Alkaabi, Sara
core   +2 more sources

New and emerging options for management of invasive fungal diseases in paediatric patients

Mycoses, Volume 67, Issue 1, January 2024.
Abstract Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals.
Andreas H. Groll, Katharina Körholz, Malcolm Holterhus, Thomas Lehrnbecher   +3 more
wiley   +1 more source

Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches

Infection and Drug Resistance, 2021
Anna Maria Tortorano,1 Anna Prigitano,1 Gianluca Morroni,2 Lucia Brescini,2,3 Francesco Barchiesi2,4 1Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy; 2Department of Biomedical Sciences and Public Health ...
Tortorano AM, Prigitano A, Morroni G, Brescini L, Barchiesi F   +4 more
doaj  

A phase 1 open label study to assess the human mass balance and metabolite profile of ¹⁴C-fosmanogepix, a novel Gwt-1 inhibitor in healthy male participants. [PDF]

Antimicrob Agents Chemother
ABSTRACT Fosmanogepix [FMGX; active form manogepix (MGX)], a novel antifungal, is currently being studied for the treatment of invasive fungal diseases caused by Candida spp., Aspergillus spp., and other rare molds. This Phase 1, single-dose study
Hodges MR, Ople E, Evans P, Pantophlet AJ(, Richardson J, Williams D, Tripathy S, Tawadrous M, Jakate A.   +8 more
europepmc   +3 more sources