Results 191 to 200 of about 1,630,396 (293)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Rating certainty when the target threshold is the null and the point estimate is close to the null. [PDF]

BMJ Evid Based Med
Zeng L, Hultcrantz M, Tovey D, Santesso N, Dahm P, Brignardello-Petersen R, Mustafa RA, Murad MH, Izcovich A, de Beer H, Ragusa MA, Johnston B, Zhang L, Iorio A, Guyatt G.   +14 more
europepmc   +1 more source

Is the remodeling pattern consistent throughout an atherosclerotic lesion? Intravascular ultrasound evidence of heterogeneity within a single diseased segment Atila Iyisoy, Khaled M. Ziada, Mohammed Balghith, Allen Jeremias, Hiroshi Tsutsui, Samir R. Kapadia, Paul Schoenhagen, Mandish Rai, Steven E. Nissen, E. Murat Tuzcu. Cleveland Clinic foundation, Cleveland, OH

, 2001

openalex   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Intraoperative and Short-Term Postoperative Outcomes Associated With Transoral Robotic Surgery: A Protocol for a Scoping Review. [PDF]

Acta Anaesthesiol Scand
Larsen AA, Hovind MF, Tsuchiya EA, Christensen A, Heiberg J, Krag M, Strøm C.   +6 more
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Reply to Royka and Santos: Representing ignorance, and the evolution of theory of mind. [PDF]

Proc Natl Acad Sci U S A
Townrow LA, Krupenye C.
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Scientia machina: a proposed conceptual framework for a technology-accelerated system of biomedical science

Frontiers in Systems Biology
Sean T. Manion, Sean T. Manion
doaj   +1 more source

Neurocomputational mechanisms of personal benefits and justifications in moral decision-making. [PDF]

Commun Biol
Sai L, Wang C, Lv Y, Bellucci G.
europepmc   +1 more source