Results 201 to 210 of about 4,276,534 (360)

Does school autonomy improve educational outcomes? Judging the performance of foundation secondary schools in England [PDF]

Government and researchers use school performance measures such as contextual value-added to claim that giving schools autonomy from local authority control produces superior pupil performance in GCSE examinations. This paper explores the extent to which
Rebecca Allen
core  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Evidence and the micro-foundations of economic growth [PDF]

Economics and Business Review, 2017
openaire   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

294 ACUPUNCTURE FOR OVERACTIVE BLADDER IN ADULTS: A COCHRANE REVIEW

Continence, 2022
E Hargreaves, Y Zhang, X Zhang, C Harding, K Baker, G Barry, N Kandala, C Clarkson   +7 more
doaj  

Accelerated evidence synthesis in orthopaedics—the roles of natural language processing, expert annotation and large language models

Journal of Experimental Orthopaedics, 2023
Bálint Zsidai, Janina Kaarre, Ann‐Sophie Hilkert, Eric Narup, Eric Hamrin Senorski, Alberto Grassi, Olufemi R. Ayeni, Volker Musahl, Christophe Ley, Elmar Herbst, Michael T. Hirschmann, Sebastian Kopf, Romain Seil, Thomas Tischer, Kristian Samuelsson, Robert Feldt, ESSKA Artificial Intelligence Working Group   +16 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Regulation of Phosphate Uptake in Primary Cultured Rabbit Renal Proximal Tubule Cells by Glucocorticoids: Evidence for Nongenomic as Well as Genomic Mechanisms**This work was supported by grants awarded to Dr. H. J. Han from Korea Science and Engineering Foundation (KOSEF 971-0605-036–2, HRC 1998G0301). [PDF]

, 2001
Soo-Hyun Park, Mary Taub, Ho Jae Han
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Cystic Fibrosis Foundation Evidence-Based Guideline for the Management of CRMS/CFSPID. [PDF]

Pediatrics
Green DM, Lahiri T, Raraigh KS, Ruiz F, Spano J, Antos N, Bonitz L, Christon L, Gregoire-Bottex M, Hale JE, Langfelder-Schwind E, La Parra Perez Á, Maguiness K, Massie J, McElroy-Barker E, McGarry ME, Mercier A, Munck A, Oliver KE, Self S, Singh K, Smiley M, Snodgrass S, Tluczek A, Tuley P, Lomas P, Wong E, Hempstead SE, Faro A, Ren CL.   +29 more
europepmc   +1 more source