Results 201 to 210 of about 8,424,075 (351)

The Empirical Zoo Director—Building a Foundation of Evidence-Based Welfare and Wellness: Keynote [PDF]

, 2013
Terry L. Maple
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland

New Microbes and New Infections, EarlyView., 2014
Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini, I. Magouras, C. Chapuis‐Taillard, O. Clerc, E. Masserey, G. Peduto, O. Péter, S. Schaerrer, G. Schuepbach, G. Greub   +9 more
wiley   +1 more source

Functional Diversity of Serotonin Neurons in the Dorsal and Median Raphe Nuclei in Emotional Responses. [PDF]

Neuropsychopharmacol Rep
Ohmura Y, Nagayasu K.
europepmc   +1 more source

CopilotCAD: Empowering Radiologists with Report Completion Models and Quantitative Evidence from Medical Image Foundation Models [PDF]

Sheng Wang, Tianming Du, Katherine Fischer, Gregory E. Tasian, Justin Ziemba, Joanie M. Garratt, Hersh Sagreiya, Yong Fan   +7 more
openalex   +1 more source

Evidence‐based knowledge on the aesthetics and maintenance of peri‐implant soft tissues: Osteology Foundation Consensus Report Part 1—Effects of soft tissue augmentation procedures on the maintenance of peri‐implant soft tissue health [PDF]

, 2018
William V. Giannobile, Ronald E. Jung, Frank Schwarz   +2 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Foundation for an evidence‐informed algorithm for treating pelvic floor mesh complications: a review [PDF]

, 2018
GW Cundiff, DJ Quinlan, JA van Rensburg, Mark Slack   +3 more
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson's Disease. [PDF]

NPJ Parkinsons Dis
Mammen JR, Adams JL, Mangrum R, Xiao Y, Barbosa W, Tyo M, Redmond C, Carter C, Cifelli K, Cifelli R, Maruzo H, Meeker J, Shultz G, Thomas C, Bale C, Davies E, Kopil CM, Marras C, Mestre T, Morel T, Simuni T, Stebbins GT, Weintraub D, Stephenson D.   +23 more
europepmc   +1 more source