Results 81 to 90 of about 8,780,344 (351)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Research evidence communication for policy-makers: a rapid scoping review on frameworks, guidance and tools, and barriers and facilitators

Health Research Policy and Systems
Background Communication is a multifaceted process, ranging from linear, one-way approaches, such as transmitting a simple message, to continuous exchanges and feedback loops among stakeholders.
Jorge Otávio Maia Barreto, Roberta Crevelário de Melo, Letícia Aparecida Lopes Bezerra da Silva, Bruna Carolina de Araújo, Cintia de Freitas Oliveira, Tereza Setsuko Toma, Maritsa Carla de Bortoli, Peter Nichols Demaio, Tanja Kuchenmüller   +8 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Application of artificial intelligence to measure and predict patient values and preferences: a scoping review

npj Digital Medicine
Patients’ voices are often difficult to capture directly in healthcare decisions. This scoping review examines how artificial intelligence (AI) has been applied to measure and predict patient values and preferences, aiming to evaluate its potential to ...
Mengting Yang, Yuan Luo, Tong He, Sha Diao, Hailong Li, Kun Zou, Glen Stewart Hazlewood, Per Olav Vandvik, Leticia Kawano-Dourado, Daniel de Araujo Dourado, Krista Dagsvik, Xiaoxi Zeng, Wei Zhang, Lingli Zhang, Linan Zeng   +14 more
doaj   +1 more source

Multicomponent hospital-led interventions to reduce hospital stay for older adults following elective surgery: a systematic review

Health Services and Delivery Research, 2019
Background: Elective older adult inpatient admissions are increasingly common. Older adults are at an elevated risk of adverse events in hospital, potentially increasing with lengthier hospital stay.
Michael Nunns, Liz Shaw, Simon Briscoe, Jo Thompson Coon, Anthony Hemsley, John S McGrath, Christopher J Lovegrove, David Thomas, Rob Anderson   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Foundations of probabilistic inference with uncertain evidence

International Journal of Approximate Reasoning, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Groen, Frank J., Mosleh, Ali
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Process evaluation of a National Primary Eye Care Programme in Rwanda

BMC Health Services Research, 2018
Background Visual impairment is a global public health problem, with an estimated 285 million affected globally, of which 43% are due to refractive error.
Jennifer L. Y. Yip, Tess Bright, Sebastian Ford, Wanjiku Mathenge, Hannah Faal, on behalf of the Rwanda Primary Eye Care Process evaluation group   +5 more
doaj   +1 more source