Results 81 to 90 of about 11,048,783 (373)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Oregon Parenting Education Collaborative: Helping Parents Raise Children Who Thrive [PDF]

, 2015
This report summarizes the work of the Oregon Parenting Education Collaborative during its first five years, 2010-2015. OPEC is a multi-year initiative led by The Oregon Community Foundation, The Ford Family Foundation and Oregon State University ...
Bill Graves
core  

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Research Integrity and Peer Review—past highlights and future directions

Research Integrity and Peer Review, 2018
In May 2016, we launched Research Integrity and Peer Review, an international, open access journal with fully open peer review (reviewers are identified on their reports and named reports are published alongside the article) to provide a home for ...
Stephanie L. Boughton, Maria K. Kowalczuk, Joerg J. Meerpohl, Elizabeth Wager, Elizabeth C. Moylan   +4 more
doaj   +1 more source

Working Paper, Rents and Inefficiency in the Patent and Copyright System: Is There a Better Route? [PDF]

, 2016
This paper analyzes the evidence for rents due to the patent and copyright systems for financing innovation and creative work. It notes research suggesting that in both the patent and copyright system, the costs in the form of monopoly pricing and rent ...
Dean Baker
core  

Animals and Cotswold-Severn long-barrows: a re-examination. [PDF]

, 2010
In this paper new collaborative research is presented following a re-examination of the faunal remains and architectural evidence from a selected number of Cotswold-Severn long barrow sites. Five different loci of deposition are considered: ‘pre-barrow’
McFadyen, Lesley
core   +1 more source

2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis

Arthritis care & research, 2018
Objective: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF ...
Jasvinder A. Singh, G. Guyatt, A. Ogdie, D. Gladman, C. Deal, A. Deodhar, M. Dubreuil, J. Dunham, M. E. Husni, Sarah Kenny, J. Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, J. F. Merola, Julie Miner, Christopher T. Ritchlin, B. Siaton, Benjamin J. Smith, A. V. Van Voorhees, A. Jonsson, A. A. Shah, Nancy M. Sullivan, Marat Turgunbaev, Laura C. Coates, A. Gottlieb, M. Magrey, W. B. Nowell, A. Orbai, Soumya M. Reddy, J. Scher, E. Siegel, M. Siegel, Jessica A Walsh, Amy S. Turner, J. Reston   +35 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Ultrasound-Based Scoring System for Indication of Pyeloplasty in Patients With UPJO-Like Hydronephrosis

Frontiers in Pediatrics, 2020
Background: Previous scoring systems have used renal scan parameters to assess severity of ureteropelvic junction obstruction-like hydronephrosis (UPJO-like HN), however this information is not always reliable due to protocol variation across centers and
Bruce Li, Melissa McGrath, Melissa McGrath, Melissa McGrath, Forough Farrokhyar, Forough Farrokhyar, Luis H. Braga, Luis H. Braga, Luis H. Braga, Luis H. Braga   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source