Results 231 to 240 of about 3,264,360 (304)

Public contributions to the development of antibiotics: two successful and two failed investments. [PDF]

J Pharm Policy Pract
Schmidt L, Sehic O, Theuretzbacher U, Wild C.   +3 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Power-efficient ultra-broadband soliton microcombs in resonantly-coupled microresonators. [PDF]

Light Sci Appl
Zhu K, Luo X, Wang Y, Wang Z, Xu T, Qian D, Cheng Y, Wang J, Luo H, Liu Y, Jin X, Xie Z, Zhou X, Wang M, Liu JF, Cao X, Wang T, Tang SJ, Gong Q, Li BB, Yang QF.   +20 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Facet-modulated ferroelectric polymers. [PDF]

Nat Commun
Cai B, Hou ZL, Qi YY, Zhao PY, Peng HL, Zhang Y, Koo MC, Yue T, Hu P, Liu LM, Wang GS.   +10 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Addressing Parental Supply of Alcohol to Teens: Development and Message Testing of the Keep Their Future Bright Campaign. [PDF]

Health Promot J Austr
Harding N, Chenery M, McPhie S, Fredheim S, Bovopoulos N, Martin C, Marrocco C.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Is three-phase bone scintigraphy really obsolete? : a combined TPBS-CRP diagnostic method. [PDF]

Bone Joint Res
Chen Q, Li Y, Guo X, Wlamu W, Mu W, Ji B, Cao L, Zhang X.   +7 more
europepmc   +1 more source

Foundation phase child development profile : guidance = Cyfnod sylfaen proffil datblygiad plentyn : canllawiau [PDF]

, 2009

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