Results 51 to 60 of about 254,392 (284)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Study on Deformation Characteristics of Deep Foundation Pit Soil and Retaining Structure of Subway Station in Guangzhou Area With Composite Strata

open access: yesAdvances in Civil Engineering
The excavation of the deep foundation pit of subway station may cause excessive deformation of foundation pit and retaining structure and then pose a threat to the safety of surrounding buildings and people.
Wufeng Mao   +3 more
doaj   +1 more source

Deformation Control for Foundation Pit Segmented Construction Adjacent to Operational High-speed Railway Lines

open access: yesChengshi guidao jiaotong yanjiu
Objective Limited land use resource and arrangement adjacent to operational high-speed railway lines pose significant challenges to some city foundation pit constructions and the railway operational safety.
LI Xiaolong   +5 more
doaj   +1 more source

A Review of State Revenue Actions, 1999-2010 [PDF]

open access: yes, 2010
This report examines tax and other revenue changes enacted by the states since 1999 with particular focus on Georgia's Southeast and AAA-rated peers, and how states have dealt with budget gaps in two post-recession ...
Robert Buschman
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Study on Anti-Heave Stability and Deformation Characteristics of Narrow Foundation Pits in Ningbo Metro

open access: yesChengshi guidao jiaotong yanjiu
[Objective] Compared with wide foundation pits, the stress and displacement field changes of the soil at pit bottom and outside caused by narrow foundation pit excavation are smaller.
YAO Renxing   +4 more
doaj   +1 more source

Nonequilibrium spectral diffusion due to laser heating in stimulated photon echo spectroscopy of low temperature glasses

open access: yes, 1997
A quantitative theory is developed, which accounts for heating artifacts in three-pulse photon echo (3PE) experiments. The heat diffusion equation is solved and the average value of the temperature in the focal volume of the laser is determined as a ...
A. Heuer   +30 more
core   +1 more source

An enamel-painted glass bottle from a “Turkish pit” in Buda [PDF]

open access: yes, 2013
The fragments of a high quality, enamel painted, blue glass bottle with the date 1671 on its shoulder were found in the Castle District of Buda, in a huge pit dated to the period of the Ottoman occupation. The shape of the object shows eastern influences,
Katona I.   +4 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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