Results 181 to 190 of about 528,283 (301)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study. [PDF]

Cardiovasc Diabetol
González-Lleó AM, Brito-Casillas Y, Martín-Santana V, Gil-Quintana Y, Tugores A, Scicali R, Riaño M, Hernández-Baraza L, Jiménez-Monzón R, Girona J, Di Giacomo Barbagallo F, Masana L, Boronat M, Wägner AM, Sánchez-Hernández RM.   +14 more
europepmc   +1 more source

Highly Elevated Prevalence of Spinobulbar Muscular Atrophy in Indigenous Communities in Canada Due to a Founder Effect. [PDF]

Neurol Genet, 2021
Leckie JN, Joel MM, Martens K, King A, King M, Korngut LW, de Koning APJ, Pfeffer G, Schellenberg KL.   +8 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Combined Evidence Reveals the Origin of a Rapid Range Expansion Despite Retained Genetic Diversity and a Weak Founder Effect. [PDF]

Mol Ecol
Bergman NM, Lehikoinen P, Kluen E, Bensch S, Lo Cascio Sætre C, Eroukhmanoff F, Fossøy F, Procházka P, Smith WJ, Stokke BG, Primmer CR, Thorogood R, Rönkä K.   +12 more
europepmc   +1 more source

Prevalent Pathogenic Variants of ATP7B in Chinese Patients with Wilson's Disease: Geographical Distribution and Founder Effect. [PDF]

Genes (Basel), 2021
Yang GM, Wang RM, Xia N, Zheng ZW, Dong Y, Wu ZY.   +5 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mucopolysaccharidosis type I: founder effect of the p.P533R mutation in North Africa. [PDF]

BMC Genomics
Chkioua L, El Fissi H, Amri Y, Sahli C, Bouzid F, Boudabous H, Tbib N, Ferchichi S, Massoud T, Alif N, Laradi S, Ben Abdennebi H.   +11 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Inherited CARD9 Deficiency Due to a Founder Effect in East Asia. [PDF]

J Clin Immunol
Tomomasa D, Lee BH, Hirata Y, Inoue Y, Majima H, Imanaka Y, Asano T, Katakami T, Lee J, Hijikata A, Worakitchanon W, Yang X, Wang X, Watanabe A, Kamei K, Kageyama Y, Seo GH, Fujimoto A, Casanova JL, Puel A, Morio T, Okada S, Kanegane H.   +22 more
europepmc   +1 more source