Results 191 to 200 of about 528,283 (301)

Evidence for human-caused founder effect in populations of Solanum jamesii found at archaeological sites: I. Breeding experiments and the geography of sexual reproduction. [PDF]

Am J Bot, 2021
Pavlik BM, Baker M, Bamberg J, Del Rio A, Kinder D, Louderback LA.   +5 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Extreme founder effect associated with hyperglycemia and hyperlipidemia on the island of NIAS/Indonesia. [PDF]

Atheroscler Plus
Kennerknecht I, Hämmerle JM, Fobker M, Nofer JR.   +3 more
europepmc   +1 more source

The Viral Founder Effect and Economic-Driven Human Mobility Shaped the Distinct Epidemic Pattern of HIV-1 CRF01_AE in Northeast China. [PDF]

Front Med (Lausanne), 2021
An M, Zhao B, Wang L, Chu Z, Xu J, Ding H, Han X, Shang H.   +7 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Successes of an innovative population-based carrier screening program for 4 prevalent recessive hereditary diseases in a population with a founder effect in Quebec, Canada. [PDF]

Genet Med Open
Fortin CA, Côté-Richer M, Truchon K, Leblanc J, Pratte A, Tardif J, Thomas MJ, Villeneuve J, Mathieu J, Grimard D, Desmeules M, Moreau C, Girard S, Cruz-Marino T, Bouchard L.   +14 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The genetics of recurrent hydatidiform moles in Mexico: further evidence of a strong founder effect for one mutation in NLRP7 and its widespread. [PDF]

J Assist Reprod Genet, 2021
Aguinaga M, Rezaei M, Monroy I, Mechtouf N, Pérez J, Moreno E, Valdespino Y, Galaz C, Razo G, Medina D, Piña R, Slim R.   +11 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

High Occurrence of a Missense Variant (c.471C>A) in the <i>FGF23</i> Gene Related to Hyperostosis-Hyperphosphatemia Syndrome With a Possible Founder Effect. [PDF]

Hum Mutat
Sedghi M, Gharehdaghi EE, Ziaee V, Abbasi F, Meybodi HRA, Smiley E, Mehdizadeh M, Raeeskarami SR, Aslani N, Shiran SN, Vafadar M, Amoli MM.   +11 more
europepmc   +1 more source