Results 61 to 70 of about 108,171 (302)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Planta Daninha, 2006 Espécies de plantas daninhas apresentam elevada variabilidade genética entre plantas dentro de uma população e exibem potencial para adaptar-se ao manejo realizado para o seu controle.
R.A. Vidal +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
Equity crowdfunding founder teams: Campaign success and venture failure [PDF]
, 2022 This paper examines whether solo founders are more likely to succeed in an initial equity crowdfunding (ECF) campaign and are subsequently less likely to fail than founder teams for a large sample of initial ECF campaigns conducted on the three largest ...
Linares Zegarra, Jose +7 more
core +1 more source
Molecular Genetics & Genomic Medicine, 2019 Background Dysferlinopathies are a group of autosomal recessive limb‐girdle muscular dystrophies (LGMDs) caused by mutations in DYSF (#603,009). This gene encodes a transmembrane protein called dysferlin.
Marzieh Mojbafan +5 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2020 Background Gaucher disease (GD) is caused by a deficiency of β-glucocerebrosidase, encoded by GBA. Haplotype analyses previously demonstrated founder effects for particular GBA mutations in Ashkenazi Jewish and French-Canadian populations.
Yoo-Mi Kim +9 more
doaj +1 more source
On the Effect of Founder Events on Epistatic Genetic Variance [PDF]
Evolution, 1987 Mayr (1963) proposed that small isolated propagules from a large panmictic population would occasionally undergo a genetic revolution due to loss of genetic variability. More recently Templeton (1980a) has suggested that founder events may be much more important in systems that have strong epistasis.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási +14 more
wiley +1 more source
Founder effect plots of QTL of percent of mice surviving to day 7.
, 2022 Analysis included 30 CC strains, after removal of CC042 and CC045. Founder effect plots for A. Chr 2 and B. 4 focused on the QTL peak, genes within the region are also shown. Results obtained using gQTL analysis. (TIF)
L. Garry Adams (10802944) +12 more
core +1 more source
HINT1 founder mutation causing axonal neuropathy with neuromyotonia in South America: A case report
Molecular Genetics & Genomic Medicine, 2021 Background Recessive loss‐of‐function mutations in HINT1 are associated with predominantly motor axonal peripheral neuropathy with neuromyotonia. Twenty‐four distinct pathogenic variants are reported all over the world, including four confirmed founder ...
Bianca deAguiar Coelho Silva Madeiro +7 more
doaj +1 more source