Results 81 to 90 of about 4,379,102 (264)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Enhanced Four-Level Active Nested Neutral Point-Clamped Inverter

Energies
The classical four-level nested neutral point-clamped (4L NNPC) inverter-leg is a hybrid of the flying-capacitor and diode-clamped 4L-inverter-leg configurations.
Charles Ikechukwu Odeh, Arkadiusz Lewicki, Marcin Morawiec, Andrzej Jąderko   +3 more
doaj   +1 more source

Four-level anterior versus posterior cervical fusions: Perioperative outcomes and five-year reoperation rates: Outcomes after four-level anterior versus posterior cervical procedures. [PDF]

N Am Spine Soc J, 2022
Joo PY, Jayaram RH, McLaughlin WM, Ameri B, Kammien AJ, Arnold PM, Grauer JN.   +6 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Four-Level Micro-Via Technology (4LµV) for ASIC Integration in Active Flexible Sensor Arrays. [PDF]

Sensors (Basel), 2022
Zhou M, von der Heide C, Dietzel A.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Interaction of a Four-Level Atom with a Deformed Quantum Field: Mathematical Model and Quantum Resources

Axioms
We introduce a framework presenting the interaction between a four-level atom (F-LA) and a field mode that begins in a coherent state within the para-Bose field (P-BF). The F-LA is considered in a cascade configuration and initially prepared in the upper
Mariam Algarni, Sayed Abdel-Khalek, Kamal Berrada   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Simplified Carrier-Based SVDPWM Methods Using Reduced Common Mode Voltage Vector Redundancy for Improving Output Current Ripple in Four-Level NPC Inverter

IEEE Access
In this article, new fast and Three-level reduced common-mode voltage (RCMV) space vector Discontinuous pulse width modulation (SVDPWM) strategies are proposed to achieve high performance in four-level neutral point clamped (4L-NPC) inverters.
Le Nam Pham, Quoc Dung Phan, Nho-van Nguyen   +2 more
doaj   +1 more source

Anterior cervical discectomy and fusion, open-door laminoplasty, or laminectomy with fusion: Which is the better treatment for four-level cervical spondylotic myelopathy? [PDF]

Front Surg, 2022
Zhong H, Xu C, Wang R, Wu X, Wu H, Sun B, Wang X, Chen H, Shen X, Yuan W.   +9 more
europepmc   +1 more source