Results 91 to 100 of about 7,684 (200)

Advanced Granulosa Cell Tumors of the Ovary: A Review with a Focus on Current and Novel Therapeutic Approaches [PDF]

Journal of Immunotherapy and Precision Oncology
Granulosa cell tumor (GCT) is the most common nonepithelial ovarian malignancy. Still, it is considered rare, with a paucity of high-level evidence guiding management, particularly in the metastatic setting.
Mohamad A. Salkeni, Sarah Shin, Naoko Takebe, Sally Stevens, Alice Chen   +4 more
doaj   +1 more source

Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles. [PDF]

PLoS ONE, 2015
Forkhead box L2 (FOXL2) is a member of the forkhead nuclear factor 3 gene family and plays an essential role in ovarian growth and maturation in mammals.
Ning Qin, Xian-Cong Fan, Xiao-Xing Xu, Thobela Louis Tyasi, Shi-Jun Li, Ying-Ying Zhang, Man-Li Wei, Ri-Fu Xu   +7 more
doaj   +1 more source

Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads [PDF]

, 2014
The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary ...
Capel, Blanche, Hinson, Ashley, Kobayashi, Akio, Maatouk, Danielle M., McMahon, Andrew P., Mork, Lindsey   +5 more
core   +1 more source

Zinc Deficiency Disrupts Germ Cell Nest Breakdown During In Vitro Ovary Culture

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT In mammals, the size of the non‐renewable primordial follicle pool is established before or soon after birth. Primordial follicles, each composed of a single oocyte surrounded by somatic cells, are the only source of gametes during the entire reproductive lifespan of the female.
James M. Hester, Suzanne M. Getman, Melissa E. Pepling, Francisco J. Diaz   +3 more
wiley   +1 more source

MicroRNA‐133b stimulates ovarian estradiol synthesis by targeting Foxl2

FEBS Letters, 2013
Forkhead L2 (Foxl2) is expressed in ovarian granulosa cells and participates in steroidogenesis by transcriptionally regulating target genes such as steroidogenic acute regulatory protein (StAR) and CYP19A1. In this study, a direct link between microRNA‐133b (miR‐133b) and Foxl2‐mediated estradiol release in granulosa cells was established.
Dai, Anyi, Sun, Haixiang, Fang, Ting, Zhang, Qun, Wu, Shaogen, Jiang, Yue, Ding, Lijun, Yan, Guijun, Hu, Yali   +8 more
openaire   +2 more sources

FOXL2 antagonises the male developmental pathway in embryonic chicken gonads [PDF]

Journal of Endocrinology, 2019
FOXL2 is a conserved transcription factor with a central role in ovarian development and function. Studies in humans and mice indicate that the main role of FOXL2 is in the postnatal ovary, namely folliculogenesis. To shed light on the function and evolution of FOXL2 in the female gonad, we examined its role in embryonic avian gonads, using in ovo ...
Andrew Thomas, Major, Katie, Ayers, Justin, Chue, Kelly, Roeszler, Craig, Smith   +4 more
openaire   +2 more sources

Effects of Temperature on the Expression of Two Ovarian Differentiation-Related Genes foxl2 and cyp19a1a

Frontiers in Physiology, 2018
Exposure to stress induces a series of responses and influences a wide range of biological processes including sex differentiation in fish. The present work investigated the molecular and physiological response to thermal stress throughout the early ...
Zhi-Gang Shen, Zhi-Gang Shen, Nour Eissa, Nour Eissa, Hong Yao, Zhi-Gang Xie, Zhi-Gang Xie, Han-Ping Wang   +7 more
doaj   +1 more source

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males

Archives of Pathology & Laboratory Medicine, 2012
Context.—Granulosa cell tumors comprise less than 5% of ovarian tumors in women and are much rarer in men, with only about 20 cases reported, to our knowledge. Recently, a somatic mutation of FOXL2 was reported in virtually all adult-type granulosa cell tumors in women.
Joema F, Lima, Long, Jin, Ana Rose C, de Araujo, Michele R, Erikson-Johnson, Andre M, Oliveira, Thomas J, Sebo, Gary L, Keeney, Fabiola, Medeiros   +7 more
openaire   +2 more sources

Expression of FOXL2 in human normal pituitaries and pituitary adenomas [PDF]

Modern Pathology, 2011
Many transcription factors have important roles in the function and differentiation of the human pituitary adenomas. Forkhead box gene transcription factor L2, Foxl2, is expressed during mouse pituitary development and co-localizes with the expression of α-glycoprotein hormone subunit (αGSU).
Noboru, Egashira, Susumu, Takekoshi, Mao, Takei, Akira, Teramoto, Robert Y, Osamura   +4 more
openaire   +2 more sources