Results 101 to 110 of about 74,948 (336)

The сontribution of FOXO family transcription factor genes (FOXO1, FOXO3) to chronic obstructive pulmonary disease

Вавиловский журнал генетики и селекции
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease of the respiratory system and is the third leading cause of death worldwide. In the framework of the most relevant concepts of COPD pathogenesis, the key focus is on accelerated ...
V. A. Markelov, L. Z. Akhmadishina, T. R. Nasibullin, Y. G. Aznabaeva, O. V. Kochetova, N. N. Khusnutdinova, S. M. Izmailova, N. Sh. Zagidullin, G. F. Korytina   +8 more
doaj   +1 more source

FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

Molecular Metabolism, 2021
Objective: Forkhead box protein O1 (FOXO1) plays a key role in regulating hepatic glucose production, but investigations of FOXO1 inhibition as a potential therapeutic approach have been hampered by a lack of selective chemical inhibitors.
Yun-Kyoung Lee, Bryan Diaz, Marianne Deroose, Samuel X. Lee, Sandro Belvedere, Domenico Accili, Rudolph L. Leibel, Hua V. Lin   +7 more
doaj   +1 more source

Modeling of the human alveolar rhabdomyosarcoma Pax3-Foxo1 chromosome translocation in mouse myoblasts using CRISPR-Cas9 nuclease [PDF]

, 2015
Many recurrent chromosome translocations in cancer result in the generation of fusion genes that are directly implicated in the tumorigenic process. Precise modeling of the effects of cancer fusion genes in mice has been inaccurate, as constructs of ...
Carvajal, Jaime J., Grosveld, Gerard C., Harwood, Frank, Lagutina, Irina V., Picchione, Fabrizio, Valentine, Marcus B., Valentine, Virginia, Villarejo-Balcells, Bárbara   +7 more
core   +2 more sources

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

Nature Communications, 2019
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance.
Jin-mei Yu, Wei Sun, Zhen-he Wang, X. Liang, Fang Hua, Ke Li, Xiao-xi Lv, Xiao-wei Zhang, Yuying Liu, Jiao-jiao Yu, Shan-shan Liu, Shuang Shang, Feng Wang, Zhao-na Yang, Chen-xi Zhao, Xue-ying Hou, Ping-ping Li, B. Huang, Bing Cui, Zhuo-wei Hu   +19 more
semanticscholar   +1 more source

FOXO1 inhibition prevents renal ischemia–reperfusion injury via cAMP‐response element binding protein/PPAR‐γ coactivator‐1α‐mediated mitochondrial biogenesis

British Journal of Pharmacology, 2020
Growing evidence indicates targeting mitochondrial dynamics and biogenesis could accelerate recovery from renal ischemia–reperfusion (I/R) injury, but the underlying mechanisms remain elusive.
Di Wang, Yanqing Wang, Xiantong Zou, Yundi Shi, Qian Liu, Tianru Huyan, Jing Su, Qi Wang, Fengxue Zhang, Xuejun Li, Lu Tie   +10 more
semanticscholar   +1 more source

FOXO1 Regulates Bacteria-Induced Neutrophil Activity [PDF]

Frontiers in Immunology, 2017
Neutrophils play an essential role in the innate immune response to microbial infection and are particularly important in clearing bacterial infection. We investigated the role of the transcription factor FOXO1 in the response of neutrophils to bacterial challenge with Porphyromonas gingivalis in vivo and in vitro.
Guangyu Dong, Liang Song, Liang Song, Chen Tian, Yu Wang, Yu Wang, Fang Miao, Fang Miao, Jiabao Zheng, Jiabao Zheng, Chanyi Lu, Sarah Alsadun, Dana T. Graves   +12 more
openaire   +4 more sources

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Inactivation of FOXO1 induces T follicular cell polarization and involves angioimmunoblastic T cell lymphoma

Cancer Biology & Medicine, 2019
ObjectiveAngioimmunoblastic T cell lymphoma (AITL) is an aggressive form of non-Hodgkin lymphoma derived from mature T cells. However, the underlying pathogenesis of AITL remains unresolved. We aimed to explore the role of FOXO1-mediated signaling in the
Meifang Xu, Fei Wang, Hong Chen, Lin Liu, Wenwen Liu, Yinghong Yang, Qiaoling Zheng, Lihong Zhang, Xiaoxuan Li, Suxia Lin, Shengbing Zang   +10 more
doaj   +1 more source

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

Aging, 2020
Cerebral ischemia/reperfusion (CIR) injury occurs when blood flow is restored in the brain, causing secondary damage to the ischemic tissues. Previous studies have shown that electroacupuncture (EA) treatment contributes to brain protection against CIR ...
Zhigang Mei, Ya-guang Huang, Zhitao Feng, Ya-nan Luo, Song-bai Yang, Lipeng Du, Kang Jiang, Xiao-Lu Liu, Xianyun Fu, Yi-Hui Deng, Hua-jun Zhou   +10 more
semanticscholar   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source