Results 211 to 220 of about 74,948 (336)

FOXO1 mediates miR-99a-5p/E2F7 to restrain breast cancer cell proliferation and induce apoptosis

BMC Cancer
Background FOXO1 is known to act as a tumor suppressor gene in breast cancer, but its exact mechanism of action remains unclear. Objective This study aimed to clarify how FOXO1 suppresses breast cancer cell proliferation and induces apoptosis.
Ying Zhang, Haili Wang, Yiliang Wang, Bo Ma   +3 more
doaj   +1 more source

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Matthieu Leuillier, Mustapha Chelgham, Hind Messaoudi, Ly Tu, Severine Ménoret, Raphaël Thuillet, Déborah Groussard, Felix F. Lillich, Mina Ottaviani, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Ignacio Anegon, Christophe Morisseau, Ewgenij Proschak, Christophe Guignabert, Jérémy Bellien   +17 more
wiley   +1 more source

Anticancer Activity of Methyl Protodioscin against Prostate Cancer by Modulation of Cholesterol-Associated MAPK Signaling Pathway <i>via</i> FOXO1 Induction

, 2023
Jie Chen, Puyan Qin, Zhanxia Tao, Weijian Ding, Yunlong Yao, Weifang Xu, Dengke Yin, Song Tan   +7 more
openalex   +2 more sources

Activation of AMPK inhibits cardiomyocyte hypertrophy by modulating of the FOXO1/MuRF1 signaling pathway in vitro [PDF]

, 2010
Baolin Chen, Yuedong Ma, Rongsen Meng, Zhaojun Xiong, Hai‐Ning Wang, Junyi Zeng, Chen Liu, Yugang Dong   +7 more
openalex   +1 more source

Fetal Hypoxia Caused Autophagy in Ovary Granulosa Cells Via PI3K/Akt/FoxO1 Pathway and Rescued by Melatonin

, 2023
Luyao Zhang, Kexiong Liu, Zhiqiang Liu, Hai-Ping Tao, Xiangwei Fu, Jian Hou, Gongxue Jia, Yunpeng Hou   +7 more
openalex   +1 more source

Selective FOXO1 modulation [PDF]

Nature Reviews Drug Discovery, 2017
openaire   +1 more source

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source

Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase

Scientific Reports
The transcription factor Forkhead box protein O1 (FoxO1) is a well-established regulator of glucose and lipid metabolism, yet its role in metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis remains debated.
Hui-Ting Chen, Chen Huang, Jia-Wei Chen, Si-Qi Yang, Jie-Min Cheng, Yong-Qiang Li, Han-Qing Chen, Yong-Jian Zhou   +7 more
doaj   +1 more source

Process Systems Engineering in Precision Medicine: Opportunities in Autologous CAR‐T Therapy

Engineering in Life Sciences, Volume 26, Issue 2, February 2026.
ABSTRACT Autologous chimeric antigen receptor (CAR)‐T therapies have given hope to many cancer patients whose other lines of treatment have failed. Unfortunately, limited manufacturing capability has resulted in many patients dying while on a waitlist.
B. Wayne Bequette
wiley   +1 more source

Data from Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3–FOXO1-Positive Alveolar Rhabdomyosarcoma

, 2023
Julie J.G. Kephart, Rosanne G.J. Tiller, Lisa E.S. Crose, Katherine K. Slemmons, Po‐Han Chen, Ashley R. Hinson, Rex C. Bentley, Jen‐Tsan Chi, Corinne M. Linardic   +8 more
openalex   +1 more source