Results 71 to 80 of about 74,948 (336)

FOXO1 Up-Regulates Human L-selectin Expression through Binding to a Consensus FOXO1 Motif [PDF]

Gene Regulation and Systems Biology, 2012
L-selectin plays important roles in lymphocyte homing and leukocyte rolling. Mounting evidence shows that it is involved in many disease entities including diabetes, ischemia/reperfusion injuries, inflammatory diseases, and tumor metastasis. Regulation of L-selectin at protein level has been well characterized.
Lou, Yuefen, Lu, Xiaojiong, Dang, Xitong
openaire   +2 more sources

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Nature
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma1–4, but the efficacy of CAR T cell therapy in solid tumours has been ...
Jack D. Chan, Christina M Scheffler, Isabelle Munoz, K. Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y. L. Saw, Jasmine Li, Amanda X. Y. Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N. de Menezes, Emma V. Petley, Joelle S Kim, DatMinh Nguyen, Patrick S K Leung, Joan So, C. Deguit, J. Zhu, Imran G. House, Lev M. Kats, Andrew M Scott, Benjamin J. Solomon, Simon J. Harrison, J. Oliaro, I. Parish, Kylie M. Quinn, P. Neeson, C. Slaney, Junyun Lai, P. Beavis, P. Darcy   +37 more
semanticscholar   +1 more source

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

Cells, 2020
FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals.
S. Peng, Wei Li, Nannan Hou, Niu Huang
semanticscholar   +1 more source

Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer's Disease and Huntington's Disease

Oxidative Medicine and Cellular Longevity, 2022
Alzheimer’s disease (AD) and Huntington’s disease (HD) are destructive worldwide diseases. Efforts have been made to elucidate the process of these two diseases, yet the pathogenesis remains elusive as it involves a combination of multiple factors ...
Liyang Liu, Jun Bai, Fangxi Liu, Ying Xu, Mei Zhao, Chuansheng Zhao, Zhike Zhou   +6 more
semanticscholar   +1 more source

Facteur de transcription Foxo1 [PDF]

médecine/sciences, 2008
Le facteur de transcription FoxO1 est un des acteurs cle des reponses transcriptionnelles a l’insuline et joue un role central dans l’adaptation metabolique au cours du jeune. Le role majeur de FoxO1 et de ses homologues dans la protection contre le stress oxydant et les dommages de l’ADN, et ainsi dans la determination de la longevite, est conserve ...
Mourad Naïmi, Emmanuel Van Obberghen
openaire   +1 more source

[Alveolar rhabdomyosarcoma: Two fusion-negative cases lacking PAX3-FOXO1 and PAX7-FOXO1].

Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia, 2022
Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and adolescence. Morphologically, two major forms are described: alveolar and embryonal rhabdomyosarcoma. The former is generally associated with a poorer prognosis and it usually harbors a characteristic fusion gene, PAX3/7-FOXO1, that is used to confirm the diagnosis. We present two
Mestre-Alagarda C, Gomez-Mateo M, Berenguer-Romero M, Syonghyun N, Nieto G, Navarro-Fos S   +5 more
openaire   +5 more sources

FOXO1 is a master regulator of memory programming in CAR T cells

Nature
A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in vivo1. The expression of memory-associated genes in CAR T cells is linked to their long-term persistence in patients and clinical efficacy2–6,
Alexander E Doan, Katherine P Mueller, Andy Y. Chen, Geoffrey T. Rouin, Yingshi Chen, Bence Daniel, John Lattin, M. Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, Inyoung Jung, Alice Wang, Peng Xu, D. Klysz, Gabrielle Zuern, Malek Bashti, Patrick Quinn, Zhuang Miao, Katalin D. Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan T. Logun, Junior Hall, Kai Tan, Stephan A. Grupp, Susan E. McClory, Caleb A. Lareau, J. Fraietta, E. Sotillo, Ansuman T. Satpathy, Crystal L. Mackall, Evan W. Weber   +33 more
semanticscholar   +1 more source

The role of FOXO1-mediated autophagy in the regulation of bone formation

Cell Cycle, 2022
Autophagy is essential for the maintenance of intracellular homeostasis, implicated in various biological processes. Forkhead box protein O1 (FOXO1) is regarded as a key mediator regulating skeletal development.
Yixuan Jiang, Wenqiong Luo, F. Zhou, P. Gong, Y. Xiong   +4 more
semanticscholar   +1 more source

Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications

Cells, 2019
Background: The present study was designed to explore the underlying role of hypoxia-inducible factor 1α (HIF-1α) in reactive oxygen species (ROS) formation and apoptosis in osteosarcoma (OS) cells induced by hypoxia.
Wei Sun, Bing Wang, Xing-Long Qu, Bi-Qiang Zheng, Wen-Ding Huang, Zheng-Wang Sun, Chun-Meng Wang, Yong Chen   +7 more
doaj   +1 more source

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease [PDF]

, 2014
R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases.
Alarcón, Balbino, Bustelo, Xosé R., Cañamero, Marta, de Alava, Enrique, Dosil, Mercedes, Larive, Ramon, Menacho Márquez, Mauricio Ariel, Moriggi, Giulia   +7 more
core   +3 more sources