Results 301 to 310 of about 160,147 (340)

LTF as a Potential Predictive Biomarker for Durable Benefit From First‐Line Chemo‐Immunotherapy in Small Cell Lung Cancer

Cancer Science, EarlyView.
LTF as a potential biomarker for predicting the efficacy of chemo‐immunotherapy. ABSTRACT At present, only a limited fraction of patients with extensive‐stage small cell lung cancer (ES‐SCLC) achieve a sustained response to immune checkpoint blockade (ICB) therapy.
Shimo Shen, Yili Wu, Zhuowei Shao, You Li, Di Peng, Bing Li, Zhou Zhang, Shibo Wu   +7 more
wiley   +1 more source

Influence of <i>FOXP3</i> rs2280883 and rs3761548 Variants on IL-10 and TGF-β1 Serum Levels and Plaque Psoriasis Risk in the Mexican Population. [PDF]

Int J Mol Sci
Hernández-Bello J, Preciado-Aguiar MS, Muñoz-Valle JF, Baños-Hernández CJ, García-Arellano S, Alvarado-Navarro A.   +5 more
europepmc   +1 more source

Faecalibacterium in the Gut Microbiota Predicts Tolerance Acquisition in Pediatric Hen's Egg Allergy

Allergy, EarlyView.
Shohei Akagawa, Shoji Tsuji, Yoko Nakai, Chika Urakami, Mitsuru Yamagishi, Yuko Akagawa, Kazunari Kaneko   +6 more
wiley   +1 more source

Impact of Vitamin C on Immune Response and Edema Following Near‐Infrared Photoimmunotherapy (NIR‐PIT)

Cancer Science, EarlyView.
Acute temporal edema, which can potentially obstruct the airway, is the most common adverse effect associated with near‐infrared photoimmunotherapy (NIR‐PIT) of head and neck cancer. Leveraging the chemical mechanisms of NIR‐PIT, vitamin C has been shown to suppress such edema and enhance cytotoxicity by quenching reactive oxygen species and donating ...
Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi   +10 more
wiley   +1 more source

Tolerization with a Novel Dual-Acting Liposomal Tim Agonist Prepares the Immune System for the Success of Gene Therapy. [PDF]

Int J Mol Sci
Ramadan A, Rao P, Allababidi S, Khashan R, Fathallah AM.   +4 more
europepmc   +1 more source

Dual Targeting of Aurora‐A and Bcl‐xL Synergistically Reshapes the Immune Microenvironment and Induces Apoptosis in Breast Cancer

Cancer Science, EarlyView.
The combination of the Aurora‐A kinase inhibitor MLN8237 and the BH3 mimetic ABT263 enhanced anti‐tumor immunity by boosting CD8+ T cells and natural killer cells, while reducing immunosuppressive cells in the tumor microenvironment. It induced apoptosis via extrinsic and intrinsic pathways with minimal toxicity, offering a promising therapeutic ...
Mingxue Liu, Jing Guo, Weiyong Liu, Zhenye Yang, Fazhi Yu   +4 more
wiley   +1 more source

Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics. [PDF]

Cell Death Dis
Mikulak J, Terzoli S, Marzano P, Cazzetta V, Martiniello G, Piazza R, Viano ME, Vitobello D, Portuesi R, Grizzi F, Hegazi MAAA, Fiamengo B, Basso G, Parachini L, Mannarino L, D'Incalci M, Marchini S, Mavilio D.   +17 more
europepmc   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis. [PDF]

Nat Commun
Sáenz-Narciso B, Bell SE, Matheson LS, Venigalla RKC, Turner M.   +4 more
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source