Results 301 to 310 of about 171,978 (359)

Dendritic Cell‐Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis

Hepatology Research, EarlyView.
ABSTRACT Aim Primary biliary cholangitis (PBC) is an autoimmune liver disease marked by progressive bile duct damage, leading to bile retention. Dendritic cells (DCs), as antigen‐presenting cells, are crucial for immune regulation, and their dysfunction is linked to autoimmunity.
Jiaqi Zhang, Ryo Nakagawa, Qingpeng Xu, Ke Hu, Lin Ru, Hayato Nakagawa, Yoshihiro Hirata   +6 more
wiley   +1 more source

Intravenous Immunoglobulin Elevates Regulatory T Cells in Guillain-Barré Syndrome: A Potential Biomarker of Therapeutic Response. [PDF]

J Peripher Nerv Syst
Jahan I, Ahmed R, Ahmed J, Afsar NA, Biswas PP, Khurshid S, Mohammad QD, Endtz HP, Huizinga R, Jacobs BC, Islam Z.   +10 more
europepmc   +1 more source

Regulatory T Cell Dysregulation in Vitiligo: A Meta‐Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives

International Journal of Dermatology, EarlyView.
Schematic representation of the methodology, key findings and implications in the context of immune mechanisms and treatment perspectives for vitiligo from the meta‐analysis and systematic review. ABSTRACT Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver ...
Gabriela Lerner, Maria Nikolaou, Corinne Stoffel, Eloi Schmauch, Thomas Kündig, Thierry Passeron, Julien Seneschal, Nanja van Geel, Ulrike Held, Antonios G. A. Kolios   +9 more
wiley   +1 more source

CD8+ T cells against extracellular pathogens: more than just a cytotoxic cell

Immunology &Cell Biology, EarlyView.
CD8+ T cells can induce immunopathology or disease tolerance and resistance in infections caused by extracellular pathogens. The secretion of IFNγ by CD8+ T cells can collaborate with IL‐17 for the elimination of extracellular pathogens. In addition, CD8+ T cells can restrict immunopathology through the elimination of APCs.
Rafael Cardoso Maciel Costa Silva
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Investigating tumor-infiltrating lymphocytes as predictors of lymph node metastasis in deep submucosal invasive esophageal squamous cell carcinoma: a retrospective cross-sectional study. [PDF]

J Gastroenterol
Konishi H, Urabe Y, Hatsushika Y, Masuda S, Nakamura T, Ishibashi K, Mizuno J, Takasago T, Tanaka H, Tsuboi A, Yamashita K, Hiyama Y, Kishida Y, Takigawa H, Ishikawa A, Kuwai T, Hamai Y, Murakami Y, Oka S.   +18 more
europepmc   +1 more source

T cell receptor associated transmembrane adaptor 1 (TRAT1) modulates human Th17 and Treg responses via PI3-kinase and STAT dependent mechanisms. [PDF]

Cell Commun Signal
Frey T, Kandolf-Zumpf C, Kaempf A, Schaffer K, Hollenstein M, Lampl A, Kovarik JJ, Strobl J, Stary G, Eckl-Dorna J, Schmidt R, Schmetterer KG.   +11 more
europepmc   +1 more source

Normal Treg homeostasis and suppressive function require both FOXP1 and FOXP4. [PDF]

JCI Insight
Dong D, Sindhava VJ, Ganesan A, Naradikian MS, Stephen TL, Frisch A, Valentine KM, Buza E, Wiehagen KR, Cancro MP, Morrisey EE, Tucker H, Hoyer KK, Khatri P, Maltzman JS.   +14 more
europepmc   +1 more source

Both CD8 + and CD4 + T regulatory cells are associated with poor survival in colorectal cancer

Cheng Z, Fadhil W, Mukherjee A, Jackson AM, Ilyas M, Spendlove I, Ramage JM.   +6 more
europepmc   +1 more source