Results 281 to 290 of about 134,443 (312)

MLL4 keeps Foxp3 in the loop

Nature Immunology, 2017
The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.
Dong-Mei, Zhao, Hai-Hui, Xue
openaire   +2 more sources

Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects

Nutrition, 2016
The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Aleida, Núñez Ruiz, Juan Diego, Cortés-Garcia, Nancy, Cortez-Espinosa, Paola Indira, Herrera-Rojas, Víctor Manuel, Ruíz-Rodríguez, Mariana, Salgado-Bustamante, Mariana Haydee, García-Hernández, Elizabeth, Reynaga-Hernández, Veronica Del Carmen, Martínez-Jimenez, Diana Patricia, Portales-Pérez   +9 more
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Persistent Enteropathy in a Toddler with a Novel FOXP3 Mutation and Normal FOXP3 Protein Expression

The Journal of Pediatrics, 2017
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by mutations in the FOXP3 gene. Patients usually present with a clinical triad of intractable diarrhea, diabetes, and eczema. In this patient, FOXP3 protein expression was normal, but FOXP3 Sanger sequencing confirmed the clinical suspicion of IPEX by detecting a ...
Sara, Seghezzo, Jack J, Bleesing, Zeynep Yesim, Kucuk   +2 more
openaire   +2 more sources

???????????????????????????????????? ??????????????????, FOXP3??? -?????????????????? ?? ?????????????????? ???????????????????? ?? ???????????????????? ???????????????????? ???????????? ???? ???????????? ???????????? ?????????????????????????? ??????????????

2019
Aim: to determine the relationships between the number of tumor-associated macrophages (??AM), intratumoral FOXP3??? -lymphocytes, microvessel density (MVD) in endometrial carcinomas and menstrual status of patients. Object and methods: tumor tissue samples of 73 endometrial cancer (EC) patients with clinical stage I???II aged 26 to 75 (mean age 56.3 ??
openaire   +1 more source

Genetic Tracing Reveals Transcription Factor Foxp3-Dependent and Foxp3-Independent Functionality of Peripherally Induced Treg Cells

Immunity, 2022
Yuri Pritykin, Talal A Chatila, Fanny Matheis   +2 more
exaly  

Distinct Foxp3 Enhancer Elements Coordinate Development, Maintenance, and Function of Regulatory T Cells

Immunity, 2021
Norihisa Mikami, Hitomi Watanabe, Shimon Sakaguchi   +2 more
exaly  

???????????????? ???????????????????? ???????? Foxp3 ?? T-???????????????????????? ?????????????? ?? ???????????????????? ?????????????? ?????????????????????????? ???????????? ????????????????, ???????????????????????????? ???????????????????????????????????????? ???????????????????? ????????????????????

2018
?? ???????????? ?????????????????????? ???????????????????? ??-???????????????????????? ???????????? (????????) ?? ?????????????? ???????????????????? ?? ?????? ???????? Foxp3 ?? ?????????????????????? ?? ???????????????? ?????????????????????????? ???????????? ???????????????? (????????), ???????????????????????????? ?????????????????? ????????????????
openaire   +1 more source

The Transcription Factor FoxP3 Can Fold Into Two Dimerization States With Divergent Implications for Regulatory T Cell Function and Immune Homeostasis

Immunity, 2022
Fangwei Leng
exaly  

Human FOXP3 and Tumour Microenvironment

Immunology, 2023
He Ren, Jia Wang, Gong Ruining
exaly  

FOXP3 (in)stability and cancer immunotherapy

Cytokine
Dysregulation of regulatory T cells (Tregs) is described in the context of inflammatory and autoimmune diseases, and cancer. Forkhead box P3 (FOXP3) is a transcription factor that its activity is an indicator of Treg identity. FOXP3 induces metabolic versatility in intra-tumoral Tregs, so that its deficiency mediates Treg instability or even gives rise
openaire   +2 more sources