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The Regulation of Immune Tolerance by FOXP3 [PDF]
Nature Reviews Immunology, 2017 The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes.
Fan Pan, Ling Lu, Joseph Barbi
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Annals of the New York Academy of Sciences, 2008
Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Jane H, Buckner, Steven F, Ziegler
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Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Jane H, Buckner, Steven F, Ziegler
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Human FOXP3 and tumour microenvironment
Immunology, 2022Abstract The tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses.
Jia Wang +5 more
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Annual Review of Immunology, 2006
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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Role of Activin A in the Induction of Foxp3+ and Foxp3− CD4+ Regulatory T Cells
Critical Reviews™ in Immunology, 2011Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious
Samuel, Huber, Christoph, Schramm
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FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity
Immunologic Research, 2008Forkhead box protein P3 (FOXP3) contributes to a unique transcriptional signature and serves as a functional marker of CD4(+)CD25(+) natural regulatory T cells. Dysfunction of FOXP3 in human is associated with fatal autoimmune disease known as immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) or X-linked autoimmunity ...
Zhaocai, Zhou +3 more
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FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
Trends in Pharmacological Sciences, 2011Naturally arising CD4(+)CD25(+) regulatory T cells (Tregs), which specifically express the forkhead family transcription factor FOXP3, are essential for the maintenance of immunological self-tolerance and immune homeostasis. Tregs can suppress the activation, proliferation and effector function of other lymphocytes in physiological and pathological ...
Naganari, Ohkura +2 more
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Insights into transcriptional regulation by FOXP3
Frontiers in Bioscience, 2006FoxP3 recently entered the spotlight as a critical component of regulatory T cell development and function. Several groups are presently engaged in an effort to uncover the mechanistic details of its contribution to this critical T cell subset. Despite this, the mechanism of FoxP3-mediated transcriptional repression and the affected target genes are ...
Bryan D, Carson +3 more
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FOXP3 gene polymorphisms in preeclampsia
American Journal of Obstetrics and Gynecology, 2012To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed.
Torri D, Metz +3 more
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2011
Regulatory T (Treg) cells play a key role in dominant suppression of immune response and maintenance of immune homeostasis. Foxp3, a member of the forkhead transcription factor family, is indispensable for Treg cell development and function. Mice and human with Foxp3 mutations are severely impaired in Treg cell generation and develop lethal autoimmune ...
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Regulatory T (Treg) cells play a key role in dominant suppression of immune response and maintenance of immune homeostasis. Foxp3, a member of the forkhead transcription factor family, is indispensable for Treg cell development and function. Mice and human with Foxp3 mutations are severely impaired in Treg cell generation and develop lethal autoimmune ...
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