Results 371 to 380 of about 199,492 (387)
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Regulatory T-Cells, FoxP3 and Atherosclerosis

2009
Innate immune responses follow accumulation of modified lipids within the arterial wall thereby influencing atherosclerotic plaque progression. One of the mechanisms evolved in maintaining immunologic self-tolerance involves upregulation of regulatory T-cells, among which the CD4+CD25+ FoxP3+ regulatory T-cells (Treg) are best characterized.
Arnon Afek   +2 more
openaire   +3 more sources

Regulatory T cells sans FoxP3

Science, 2017
Immune Regulation Although expression of FoxP3 is largely synonymous with T regulatory (Treg) cell identity in mice, type 1 regulatory T cells (TR1) are an exception. TR1 cells produce interleukin-10 but are FoxP3-negative. In comparison with FoxP3-positive Treg cells, the development and functions of TR1 cells are poorly understood.
openaire   +3 more sources

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Nature Genetics, 2001
C. Bennett   +9 more
semanticscholar   +1 more source

Foxp3+ Regulatory T Cells in Tuberculosis

2013
The immune response to Mycobacterium tuberculosis (Mtb) must be tightly regulated to mount a sufficient response to limit bacterial growth and dissemination while avoiding excessive inflammation that could damage host tissues. A wide variety of cell types, cell surface molecules, and cytokines are likely to contribute to this regulation, but recent ...
Kevin B. Urdahl   +2 more
openaire   +3 more sources

FoxP3 and Regulatory T Cells

2008
Some regulatory T cells express the Foxp3 transcription factor and such Tregs have an essential function of preventing autoimmune disease in man and mouse. Foxp3 binds to Forkhead motifs of about 1100 genes and the strength of binding increases when Foxp3-expressing T cells are stimulated by PMA and ionomycin.
Harald von Boehmer   +3 more
openaire   +2 more sources

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

Science, 2008
K. Wing   +7 more
semanticscholar   +1 more source

FOXP3+ regulatory T cells in the human immune system

Nature reviews. Immunology, 2010
S. Sakaguchi   +3 more
semanticscholar   +1 more source

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Nature Immunology, 2005
J. Fontenot   +3 more
semanticscholar   +1 more source

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