Forkhead transcription factors and cardiovascular biology. [PDF]
Circ Res, 2008 The Forkhead family of transcription factors modulates a wide variety of cellular functions in cardiovascular tissues. In this review article, we discuss recent advances in our understanding of regulation provided by the forkhead factors in cardiac myocytes and vascular cells.
Papanicolaou KN, Izumiya Y, Walsh K.
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Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 Appendage development requires the coordinated function of signaling pathways and transcription factors to pattern the leg along the three main axes: the antero-posterior (AP), proximo-distal (PD), and dorso-ventral (DV).
Mireya Ruiz-Losada +2 more
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Phylogenetic analysis of forkhead transcription factors in the Panarthropoda. [PDF]
Dev Genes Evol, 2022 AbstractFox genes encode transcription factors that contain a DNA binding domain, the forkhead domain, and are known from diverse animal species. The exact homology of the Fox genes of different species is debated and this makes inferences about the evolution of the Fox genes, and their duplications and losses difficult.
Schomburg C, Janssen R, Prpic NM.
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Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors [PDF]
Molecular Oncology, 2019 The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
Nikoleta Sachini +7 more
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Forkhead transcription factors in chronic inflammation. [PDF]
Int J Biochem Cell Biol, 2010 Forkhead (Fox) transcription factors have been increasingly recognized to play key roles in immune homeostasis, especially Foxp3 for its role in the development and function of regulatory T cells, and Foxo family members for their regulatory role in T and B lymphocytes as well as other leukocytes.
Peng SL.
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Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity. [PDF]
Cell RepSummaryRecognition of specific DNA sequences by transcription factors (TFs) is a key step in transcriptional control of gene expression. While most forkhead (FH) TFs bind either an FKH (RYAAAYA) or an FHL (GACGC) recognition motif, some FHs can bind both motifs.
King J +5 more
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Expression of Drosophila forkhead transcription factors during kidney development. [PDF]
Biochem Biophys Res Commun, 2014 The Drosophila forkhead (Dfkh) family of transcription factors has over 40 family members. One Dfkh family member, BF2 (aka FoxD1), has been shown, by targeted disruption, to be essential for kidney development. In order to determine if other Dfkh family members were involved in kidney development and to search for new members of this family, reverse ...
Baek JI +4 more
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DNA-binding specificity changes in the evolution of forkhead transcription factors. [PDF]
Proc Natl Acad Sci U S A, 2013 The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into ...
Nakagawa S +4 more
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Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]
, 2014 In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J +4 more
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Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks
Computational and Structural Biotechnology Journal, 2022 Transcription factors are regulators of the cell’s genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation.
Matteo Barberis, Thierry D.G.A. Mondeel
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