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Forkhead Transcription Factors and Cardiovascular Biology [PDF]
Circulation Research, 2008 The Forkhead family of transcription factors modulates a wide variety of cellular functions in cardiovascular tissues. In this review article, we discuss recent advances in our understanding of regulation provided by the forkhead factors in cardiac myocytes and vascular cells.
Kenneth Walsh +2 more
exaly +5 more sources
Phylogenetic analysis of forkhead transcription factors in the Panarthropoda. [PDF]
Dev Genes Evol, 2022 AbstractFox genes encode transcription factors that contain a DNA binding domain, the forkhead domain, and are known from diverse animal species. The exact homology of the Fox genes of different species is debated and this makes inferences about the evolution of the Fox genes, and their duplications and losses difficult.
Schomburg C, Janssen R, Prpic NM.
europepmc +5 more sources
Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 Appendage development requires the coordinated function of signaling pathways and transcription factors to pattern the leg along the three main axes: the antero-posterior (AP), proximo-distal (PD), and dorso-ventral (DV).
Mireya Ruiz-Losada +2 more
doaj +2 more sources
Forkhead transcription factors in chronic inflammation. [PDF]
Int J Biochem Cell Biol, 2010 Forkhead (Fox) transcription factors have been increasingly recognized to play key roles in immune homeostasis, especially Foxp3 for its role in the development and function of regulatory T cells, and Foxo family members for their regulatory role in T and B lymphocytes as well as other leukocytes.
Peng SL.
europepmc +4 more sources
Mammalian SIRT1 Represses Forkhead Transcription Factors [PDF]
Cell, 2004 The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in
Michael W Mcburney +2 more
exaly +5 more sources
Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity. [PDF]
Cell RepSummary Recognition of specific DNA sequences by transcription factors (TFs) is a key step in transcriptional control of gene expression. While most forkhead (FH) TFs bind either an FKH (RYAAAYA) or an FHL (GACGC) recognition motif, some FHs can bind both motifs.
King J +5 more
europepmc +4 more sources
Deciphering the role of forkhead transcription factors in cancer therapy. [PDF]
Curr Drug Targets, 2011 Forkhead O transcription factors (FOXO) are critical for the regulation of cell cycle arrest, cell death, and DNA damage repair. Inactivation of FOXO proteins may be associated with tumorigenesis, including breast cancer, prostate cancer, glioblastoma, rhabdomyosarcoma, and leukemia. Accumulated evidence shows that activation of oncogenic pathways such
Yang JY, Hung MC.
europepmc +4 more sources
Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors [PDF]
Molecular Oncology, 2019 The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
Nikoleta Sachini +7 more
doaj +2 more sources
The future of Forkhead box O transcription factors. [PDF]
Biochem JThe Forkhead box O (FOXO) class of transcription factors is evolutionary conserved both structurally and at least in part also functionally. FOXO activation results in transcriptional programs that provide cellular resilience toward exogenous and endogenous challenges, especially challenges that provoke cellular oxidative stress.
Huang H, Gui T, Burgering BM.
europepmc +5 more sources
DNA-binding specificity changes in the evolution of forkhead transcription factors. [PDF]
Proc Natl Acad Sci U S A, 2013 The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into dozens of subfamilies in animals, fungi, and related protists.
Nakagawa S +4 more
europepmc +7 more sources