Results 21 to 30 of about 2,538 (255)

FoxP4, a novel forkhead transcription factor [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003
Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very
Teufel, Andreas, Wong, Eric A., Mukhopadhyay, Mahua, Malik, Nasir, Westphal, Heiner   +4 more
openaire   +3 more sources

The Role of Forkhead Box Family in Bone Metabolism and Diseases

Frontiers in Pharmacology, 2022
Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease.
Jianxiang Xu, Jianxiang Xu, Jianxiang Xu, Kanbin Wang, Kanbin Wang, Kanbin Wang, Kanbin Wang, Zengjie Zhang, Zengjie Zhang, Zengjie Zhang, Deting Xue, Deting Xue, Deting Xue, Weixu Li, Weixu Li, Weixu Li, Zhijun Pan, Zhijun Pan, Zhijun Pan   +18 more
doaj   +1 more source

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network [PDF]

, 2007
Smooth muscle plays a prominent role in many fundamental processes and diseases, yet our understanding of the transcriptional network regulating its development is very limited.
Astorga (Johansson), Jeanette, Jakobsen, Janus S, Astorga, Jeanette,, Carlsson, Peter,, Furlong, E. E., Furlong, Eileen E M, Carlsson, Peter, Gustafson, E. H., Jakobsen, J. S., Braun, M., Gustafson, E Hilary, Karzynski, M., Karzynski, Michal, Sandmann, T., Sandmann, Thomas, Braun, Martina   +15 more
core   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence [PDF]

, 2010
Oncogene-induced senescence (OIS) is a potent tumor-suppressive mechanism that is thought to come at the cost of aging. The Forkhead box O (FOXO) transcription factors are regulators of life span and tumor suppression.
Marais, R., Tissue Repair, Marais, Richard, Szypowska, A.A., de Keizer, Peter L.J., Burgering, Boudewijn M.T., Dep Pathobiologie, de Bruin, A., Riedl-Polderman, Paulien E., Riedl-Polderman, P.E., Peter L.J. de Keizer, van den Broek, Niel J.F., de Keizer, P.L.J., Dansen, Tobias B., Szypowska, Anna A., Paulien E. Riedl-Polderman, Dansen, T.B., Tobias B. Dansen, Richard Marais, Packer, Leisl M., de Bruin, Alain, Boudewijn M.T. Burgering, Brenkman, Arjan B., Anna A. Szypowska, Burgering, B.M.T., Packer, L.M., Brenkman, A.B., Leisl M. Packer, van den Broek, N.J.F., Arjan B. Brenkman, Alain de Bruin, Niels J.F. van den Broek   +31 more
core   +1 more source

Gene Structure, cDNA Sequence, and mRNA Distribution [PDF]

, 1994
The rat HNF-3 (hepatocyte nuclear factor 3) gene family encodes three transcription factors known to be important in the regulation of gene expression in liver and lung.
Schütz, Günther, Kaestner, Klaus H., Hiemisch, Holger, Luckow, Bruno   +3 more
core   +1 more source

Forkhead transcription factors in the regulation of VEGF in breast cancer [PDF]

, 2011
High levels of the major angiogenic factor VEGF, have been reported in a number of cancer cell lines and in clinical specimens derived from breast.
Karadedou, Christina Theano
core   +2 more sources

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Cell Reports, 2021
Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity.
Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G. Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M.T. Burgering   +9 more
doaj   +1 more source

Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy [PDF]

Current Drug Targets, 2011
Forkhead O transcription factors (FOXO) are critical for the regulation of cell cycle arrest, cell death, and DNA damage repair. Inactivation of FOXO proteins may be associated with tumorigenesis, including breast cancer, prostate cancer, glioblastoma, rhabdomyosarcoma, and leukemia. Accumulated evidence shows that activation of oncogenic pathways such
Jer-Yen, Yang, Mien-Chie, Hung
openaire   +2 more sources

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

Molecules, 2009
Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology ...
Zhao Zhong Chong, Jinling Hou, Yan Chen Shang, Kenneth Maiese   +3 more
doaj   +1 more source