Healing the Heart with Sirtuins and Mammalian Forkhead Transcription Factors
Current Neurovascular Research, 2020 Kenneth Maiese
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Mechanism of forkhead transcription factors binding to a novel palindromic DNA site [PDF]
Nucleic Acids Research, 2021 Yongheng Chen +2 more
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The future of Forkhead box O transcription factors. [PDF]
Biochem JThe Forkhead box O (FOXO) class of transcription factors is evolutionary conserved both structurally and at least in part also functionally. FOXO activation results in transcriptional programs that provide cellular resilience toward exogenous and endogenous challenges, especially challenges that provoke cellular oxidative stress.
Huang H, Gui T, Burgering BM.
europepmc +5 more sources
FOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting [PDF]
Antioxidants(1) Background: Reactive oxygen species (ROS) act as physiological signaling mediators but contribute to oxidative damage, cellular dysfunction, and age-related disease when redox homeostasis fails.
Diana-Maria Mateescu +7 more
doaj +2 more sources
Role of forkhead transcription factors in diabetes-induced oxidative stress. [PDF]
Exp Diabetes Res, 2012 Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key ...
Ponugoti B, Dong G, Graves DT.
europepmc +2 more sources
Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks
Computational and Structural Biotechnology Journal, 2022 Transcription factors are regulators of the cell’s genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation.
Matteo Barberis, Thierry D.G.A. Mondeel
doaj +1 more source
Forkhead transcription factors and ageing [PDF]
Oncogene, 2008 Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory model organisms. Some of the mechanisms involved show evolutionary conservation, opening the way to using simpler invertebrates to understand human ageing.
L, Partridge, J C, Brüning
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. [PDF]
PLoS Biology, 2007 Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age ...
Raja Kittappa +3 more
doaj +1 more source
npj Systems Biology and Applications, 2021 Networks of interacting molecules organize topology, amount, and timing of biological functions. Systems biology concepts required to pin down ‘network motifs’ or ‘design principles’ for time-dependent processes have been developed for the cell division ...
Matteo Barberis
doaj +1 more source
FoxP4, a novel forkhead transcription factor [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003 Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very
Teufel, Andreas +4 more
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