Results 21 to 30 of about 61,376 (247)

Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes

Frontiers in Neuroscience, 2022
Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of
Ryan F. Leung, Ryan F. Leung, Ankita M. George, Enola M. Roussel, Maree C. Faux, Maree C. Faux, Maree C. Faux, Jeffrey T. Wigle, Jeffrey T. Wigle, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat   +12 more
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency

Cell Regeneration, 2021
Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear.
Meijun Fu, Huan Chen, Zepo Cai, Yihang Yang, Ziyu Feng, Mengying Zeng, Lijun Chen, Yue Qin, Baomei Cai, Pinghui Zhu, Chunhua Zhou, Shengyong Yu, Jing Guo, Jing Liu, Shangtao Cao, Duanqing Pei   +15 more
doaj   +1 more source

Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets

Cell Reports, 2017
Summary: Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian physiology to cause long-term, detrimental effects.
Adam J. Dobson, Marina Ezcurra, Charlotte E. Flanagan, Adam C. Summerfield, Matthew D.W. Piper, David Gems, Nazif Alic   +6 more
doaj   +1 more source

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics

Cancer Cell International, 2023
Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas ...
Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad, Mahdieh Soleimani   +3 more
doaj   +1 more source

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

Molecular Cancer, 2019
Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression
Paul Laissue
doaj   +1 more source

Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. [PDF]

PLoS ONE, 2009
Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors.
Uppoor G Bhat, Marianna Halasi, Andrei L Gartel   +2 more
doaj   +1 more source

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Cell Reports, 2021
Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity.
Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G. Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M.T. Burgering   +9 more
doaj   +1 more source

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

Molecules, 2009
Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology ...
Zhao Zhong Chong, Jinling Hou, Yan Chen Shang, Kenneth Maiese   +3 more
doaj   +1 more source

FoxO Proteins in the Nervous System

Analytical Cellular Pathology, 2015
Acute as well as chronic disorders of the nervous system lead to significant morbidity and mortality for millions of individuals globally. Given the ability to govern stem cell proliferation and differentiated cell survival, mammalian forkhead ...
Kenneth Maiese
doaj   +1 more source