Results 41 to 50 of about 7,923,952 (292)

FOXO transcription factors differ in their dynamics and intra/intermolecular interactions

Current Research in Structural Biology, 2022
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families.
Emil Spreitzer, T. Reid Alderson, Benjamin Bourgeois, Loretta Eggenreich, Hermann Habacher, Greta Bramerdorfer, Iva Pritišanac, Pedro A. Sánchez-Murcia, Tobias Madl   +8 more
doaj   +1 more source

Ocular forkhead transcription factors: seeing eye to eye [PDF]

The International Journal of Developmental Biology, 2009
Forkhead transcription factors comprise a large family of proteins with diverse functions during development. Recently, there has been accumulating evidence that several members of this family of proteins play an important role in the development of the vertebrate retina.
Holly E, Moose, Lisa E, Kelly, Srivamsi, Nekkalapudi, Heithem M, El-Hodiri   +3 more
openaire   +2 more sources

Analysis of the transcriptional program of developing induced regulatory T cells. [PDF]

, 2011
CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we performed
Lipsky, Peter E., Iryna Prots, Prots, Iryna, Schulze-Koops, Hendrik, Peter E. Lipsky, Alla Skapenko, Skapenko, Alla, Peter E Lipsky, Hendrik Schulze-Koops   +8 more
core   +2 more sources

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Cells, 2023
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore, Lilia Gheghiani, Zheng Fu   +2 more
doaj   +1 more source

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 [PDF]

, 2000
The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in Caenorhabditis elegans1, 2, 3.
Medema, R.H., Kops, G.J.P.L., Burgering, B.M.T., Bos, J.L.   +3 more
core   +1 more source

Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence

Journal of the Pakistan Medical Association
The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

Biomolecules, 2019
The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.
Lukáš Slavata, Josef Chmelík, Daniel Kavan, Růžena Filandrová, Jan Fiala, Michal Rosůlek, Hynek Mrázek, Zdeněk Kukačka, Karel Vališ, Petr Man, Michael Miller, William McIntyre, Daniele Fabris, Petr Novák   +13 more
doaj   +1 more source

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

Cells, 2019
FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...
Katarina Psenakova, Klara Kohoutova, Veronika Obsilova, Michael J. Ausserlechner, Vaclav Veverka, Tomas Obsil   +5 more
doaj   +1 more source