Results 41 to 50 of about 94,249 (285)

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Forkhead BoxO transcription factors restrain exercise‐induced angiogenesis [PDF]

The Journal of Physiology, 2014
Key points The growth of new capillaries, angiogenesis, within skeletal muscle occurs only after weeks of repeated aerobic exercise. Paradoxically, large increases in pro‐angiogenic factors such as vascular endothelial growth factor occur with a single exercise bout.
Dara, Slopack, Emilie, Roudier, Sammy T K, Liu, Emmanuel, Nwadozi, Olivier, Birot, Tara L, Haas   +5 more
openaire   +2 more sources

The Forkhead Transcription Factor FOXK2 Promotes AP-1-Mediated Transcriptional Regulation [PDF]

Molecular and Cellular Biology, 2012
The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs.
Ji, Zongling, Donaldson, Ian J., Liu, Jingru, Hayes, Andrew, Zeef, Leo A H, Sharrocks, Andrew D.   +5 more
openaire   +2 more sources

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Cells, 2023
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore, Lilia Gheghiani, Zheng Fu   +2 more
doaj   +1 more source

FOXM1 coming of age: time for translation into clinical benefits? [PDF]

, 2012
A decade since the first evidence implicating the cell cycle transcription factor Forkhead Box M1 (FOXM1) in human tumorigenesis, a slew of subsequent studies revealed an oncogenic role of FOXM1 in the majority of human cancers including oral ...
Teh, M-T
core   +1 more source

Forkhead Box Transcription Factors: Double-Edged Swords in Cancer

Cancer Research, 2022
Abstract A plethora of treatment options exist for cancer therapeutics, but many are limited by side effects and either intrinsic or acquired resistance. The need for more effective targeted cancer treatment has led to the focus on forkhead box (FOX) transcription factors as possible drug targets.
Maria Castaneda, Petra den Hollander, Sendurai A. Mani   +2 more
openaire   +2 more sources

Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence

Journal of the Pakistan Medical Association
The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source