Results 41 to 50 of about 2,538 (255)

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt [PDF]

Journal of Biological Chemistry, 1999
The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of ...
E D, Tang, G, Nuñez, F G, Barr, K L, Guan   +3 more
openaire   +2 more sources

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]

, 2010
Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Yanxing Yu, Lawrence S Young, Lo, KW, Dawson, Christopher W., Kwok W Lo, Lo, Angela, Angela KF Lo, Lo, Kwok W., Dawson, Christopher, Young, Lawrence, Yu, Yanxing, Lo, Angela K. F., Young, Lawrence S., Yu, Y, Christopher W Dawson   +14 more
core   +1 more source

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1

Neural Regeneration Research, 2021
The global increase in lifespan noted not only in developed nations, but also in large developing countries parallels an observed increase in a significant number of non-communicable diseases, most notable neurodegenerative disorders.
Kenneth Maiese
doaj   +1 more source

Role of forkhead transcription factors in endocrine sensitive and resistant breast cancer cell lines [PDF]

, 2010
Breast cancer is a major concern worldwide as it accounts for one of the highest causes of death. Oestrogen which is widely known for its growth-promoting function in mammary gland has been linked to breast cancer pathogenesis.
Sivanandan, Kavitta
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The mutations and potential targets of the forkhead transcription factor FOXL2 [PDF]

Molecular and Cellular Endocrinology, 2008
Mutations of FOXL2, a gene encoding a forkhead transcription factor, have been shown to cause the blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). This genetic disorder is characterized by eyelid and mild craniofacial abnormalities that can appear associated with premature ovarian failure. FOXL2 is one of the earliest ovarian markers and it
Moumné, L., Batista, F., Benayoun, B., Nallathambi, J., Fellous, M., Sundaresan, P., Veitia, R.A.   +6 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase

, 2000
Background: The ‘CLB2 cluster’ in Saccharomyces cerevisiae consists of approximately 33 genes whose transcription peaks in late G2/early M phase of the cell cycle.
Reynolds, David M., Goldstone, Sherilyn D., Stephen Dalton, Reynolds, David M, Kumar, Raman, Andrej Shevchenko, Shevchenko, Anna, Raman Kumar, Shevchenko, Andrej, Goldstone, Sherilyn D, Anna Shevchenko, Sherilyn D Goldstone, Sharma, Raman Kumar, Dalton, Stephen, David M Reynolds   +14 more
core   +1 more source

The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source

Transcriptional Dysregulation of Autophagy in Aging and Potential Interventions: Insights Into TFEB and FOXOs

Frontiers in Bioscience-Landmark
Autophagy is a highly conserved cellular degradation and recycling process essential for maintaining cellular homeostasis. However, autophagic activity declines with age, contributing to the accumulation of damaged organelles and protein aggregates.
Cheng-Ju Kuo, Denisa M. Manastireanu, Jose L. Nieto-Torres, Caroline Kumsta   +3 more
doaj   +1 more source