Results 61 to 70 of about 7,923,952 (292)

The mutations and potential targets of the forkhead transcription factor FOXL2 [PDF]

Molecular and Cellular Endocrinology, 2008
Mutations of FOXL2, a gene encoding a forkhead transcription factor, have been shown to cause the blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). This genetic disorder is characterized by eyelid and mild craniofacial abnormalities that can appear associated with premature ovarian failure. FOXL2 is one of the earliest ovarian markers and it
Moumné, L., Batista, F., Benayoun, B., Nallathambi, J., Fellous, M., Sundaresan, P., Veitia, R.A.   +6 more
openaire   +2 more sources

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors [PDF]

, 2002
AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle progression and cell death.
Medema, R.H., Dijkers, P.F., Coffer, P.J., Lam, E.W.-F., Kops, G.J.P.L., Burgering, B.M.T., Glassford, J., Essers, M.A.G.   +7 more
core   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

The Function of FoxK Transcription Factors in Diseases

Frontiers in Physiology, 2022
Forkhead box (FOX) transcription factors play a crucial role in the regulation of many diseases, being an evolutionarily conserved superfamily of transcription factors.
Mujun Yu, Haozhen Yu, Nan Mu, Yishi Wang, Heng Ma, Lu Yu   +5 more
doaj   +1 more source

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]

, 2010
Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Yanxing Yu, Lawrence S Young, Lo, KW, Dawson, Christopher W., Kwok W Lo, Lo, Angela, Angela KF Lo, Lo, Kwok W., Dawson, Christopher, Young, Lawrence, Yu, Yanxing, Lo, Angela K. F., Young, Lawrence S., Yu, Y, Christopher W Dawson   +14 more
core   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1 [PDF]

Current Biology, 2003
Stromal-epithelial interactions play an important role in renal organogenesis. Expression of the forkhead/winged helix transcription factor FoxD1 (BF-2) is restricted to stromal cells in the embryonic renal cortex, but it mediates its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to grow and differentiate in BF-2 null mice.
Zhang, Hong, Palmer, Rachel, Gao, Xiaobo, Kreidberg, Jordan, Gerald, William, Hsiao, Lili, Jensen, Roderick V., Gullans, Steven R., Haber, Daniel A.   +8 more
openaire   +2 more sources

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

FOXO Transcription Factors & Gene Expression [PDF]

, 2023
This paper attempts to highlight ForkHead box transcription factors (FOXO -1, -3, and -4) importance of subcellular localization in U87MG and ...
Keniry, Megan, Barroso, Larissa, Lopez, Alma, Reyes, Angelica M, Pintor, Shania, Flores, David, Jahan, Millat   +6 more
core   +1 more source

Advances in Research on the Mechanisms of FOXO in Renal Mitochondrial Autophagy

Xiehe Yixue Zazhi
Forkhead box O (FOXO) transcription factors serve as critical signaling hubs, initiating downstream autophagy-related gene expression in response to various growth factors and participating in mitochondrial autophagy, thereby influencing cellular damage ...
DU Xiu, SHAO Minghai, WANG Yanru, XU Lin
doaj   +1 more source