Results 81 to 90 of about 2,538 (255)

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases [PDF]

, 2016
Sirtuins (SIRT1 to -7) are unique histone deacetylases (HDACs) whose activity depends on NAD+, thus making them capable of sensing the cellular metabolic status.
Robert P. Strosznajder, Henryk Jęśko
core   +1 more source

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Diabetes, Metabolic Syndrome and Obesity, 2017
GH Tomkin,1,2 D Owens1,2 1Diabetes Institute of Ireland, Beacon Hospital, 2Trinity College, University of Dublin, Dublin, Ireland Abstract: Premature atherosclerosis in diabetes accounts for much of the decreased life span.
Tomkin GH, Owens D
doaj  

Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes [PDF]

Diabetes & Metabolism Journal
Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins ...
Hyunju Kang, Young-Ki Park, Ji-Young Lee, Minkyung Bae   +3 more
doaj   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors

Molecular Oncology, 2019
The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
Nikoleta Sachini, Panagiota Arampatzi, Antonios Klonizakis, Christoforos Nikolaou, Takis Makatounakis, Eric W.‐F. Lam, Androniki Kretsovali, Joseph Papamatheakis   +7 more
doaj   +1 more source

Forkhead-associated Domains of the Tobacco NtFHA1 Transcription Activator and the Yeast Fhl1 Forkhead Transcription Factor Are Functionally Conserved [PDF]

Journal of Biological Chemistry, 2002
NtFHA1 encodes a novel protein containing the forkhead-associated (FHA) domain and the acidic domain in Nicotiana tabacum. NtFHA1 functions as a transactivator and is targeted to the nucleus. The sequence of the FHA domain of NtFHA1 is significantly homologous to that of the Fhl1 forkhead transcription factor of yeast. FHL1 was previously identified as
Moonil, Kim, Joon-Woo, Ahn, Kiwon, Song, Kyung-Hee, Paek, Hyun-Sook, Pai   +4 more
openaire   +2 more sources

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source

The forkhead transcription factor Foxc2 stimulates osteoblast differentiation

Bone, 2009
The forkhead box C2 (Foxc2) protein is a member of the family of winged helix/forkhead transcription factors. Foxc2-deficient mice display defective formation of the aortic arches, multiple craniofacial bones, and vertebral columns. To investigate the role of Foxc2 in osteoblast differentiation, DNA containing Foxc2 was transfected into the developing ...
Lim, SK, Kim, SH, Cho, KW, Choi, HS, Park, SJ, Rhee, Y, Jung, HS   +6 more
openaire   +4 more sources

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

, 2002
AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle progression and cell death.
Medema, R.H., Dijkers, P.F., Coffer, P.J., Lam, E.W.-F., Kops, G.J.P.L., Burgering, B.M.T., Glassford, J., Essers, M.A.G.   +7 more
core   +1 more source