Results 51 to 60 of about 7,923,952 (292)
Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
npj Systems Biology and Applications, 2021 In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis
doaj +1 more source
Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro [PDF]
, 1988 The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors.
Lubon, H +5 more
core +1 more source
Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
Neural Regeneration Research, 2021 The global increase in lifespan noted not only in developed nations, but also in large developing countries parallels an observed increase in a significant number of non-communicable diseases, most notable neurodegenerative disorders.
Kenneth Maiese
doaj +1 more source
Negative Regulation of the Forkhead Transcription Factor FKHR by Akt [PDF]
Journal of Biological Chemistry, 1999 The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of ...
E D, Tang +3 more
openaire +2 more sources
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Plant Transcription Factors @ uni-potsdam.de [PDF]
, 2007 We present the Plant Transcription Factor Database (PlnTFDB), and the putative complete set of TFs in the algae _Chlamydomonas reinhardtii_, _Ostreococcus tauri_ and the vascular plants _Oryza sativa_ and _Arabidopsis ...
Slobodan Ruzicic +3 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Role of forkhead transcription factors in endocrine sensitive and resistant breast cancer cell lines [PDF]
, 2010 Breast cancer is a major concern worldwide as it accounts for one of the highest causes of death. Oestrogen which is widely known for its growth-promoting function in mammary gland has been linked to breast cancer pathogenesis.
Sivanandan, Kavitta
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Frontiers in Bioscience-LandmarkAutophagy is a highly conserved cellular degradation and recycling process essential for maintaining cellular homeostasis. However, autophagic activity declines with age, contributing to the accumulation of damaged organelles and protein aggregates.
Cheng-Ju Kuo +3 more
doaj +1 more source