Results 51 to 60 of about 2,538 (255)

The Function of FoxK Transcription Factors in Diseases

Frontiers in Physiology, 2022
Forkhead box (FOX) transcription factors play a crucial role in the regulation of many diseases, being an evolutionarily conserved superfamily of transcription factors.
Mujun Yu, Haozhen Yu, Nan Mu, Yishi Wang, Heng Ma, Lu Yu   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ocular forkhead transcription factors: seeing eye to eye [PDF]

The International Journal of Developmental Biology, 2009
Forkhead transcription factors comprise a large family of proteins with diverse functions during development. Recently, there has been accumulating evidence that several members of this family of proteins play an important role in the development of the vertebrate retina.
Holly E, Moose, Lisa E, Kelly, Srivamsi, Nekkalapudi, Heithem M, El-Hodiri   +3 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Isl1 is a direct transcriptional target of Forkhead transcription factors in second heart field-derived mesoderm

, 2009
The cells of the second heart field (SHF) contribute to the outflow tract and right ventricle, as well as to parts of the left ventricle and atria. Isl1, a member of the LIM-homeodomain transcription factor family, is expressed early in this cardiac ...
Xu, Shan-Mei, Elisha Nathan, Kang, Jione, Jione Kang, Eldad Tzahor, Brian L. Black, Black, Brian L., Nathan, Elisha, Tzahor, Eldad, Shan-Mei Xu   +9 more
core   +1 more source

Advances in Research on the Mechanisms of FOXO in Renal Mitochondrial Autophagy

Xiehe Yixue Zazhi
Forkhead box O (FOXO) transcription factors serve as critical signaling hubs, initiating downstream autophagy-related gene expression in response to various growth factors and participating in mitochondrial autophagy, thereby influencing cellular damage ...
DU Xiu, SHAO Minghai, WANG Yanru, XU Lin
doaj   +1 more source

Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1 [PDF]

Current Biology, 2003
Stromal-epithelial interactions play an important role in renal organogenesis. Expression of the forkhead/winged helix transcription factor FoxD1 (BF-2) is restricted to stromal cells in the embryonic renal cortex, but it mediates its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to grow and differentiate in BF-2 null mice.
Zhang, Hong, Palmer, Rachel, Gao, Xiaobo, Kreidberg, Jordan, Gerald, William, Hsiao, Lili, Jensen, Roderick V., Gullans, Steven R., Haber, Daniel A.   +8 more
openaire   +2 more sources

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

The future of Forkhead box O transcription factors

Biochemical Journal
The Forkhead box O (FOXO) class of transcription factors is evolutionary conserved both structurally and at least in part also functionally. FOXO activation results in transcriptional programs that provide cellular resilience toward exogenous and endogenous challenges, especially challenges that provoke cellular oxidative stress.
Huanjie Huang, Tianshu Gui, Boudewijn MT. Burgering   +2 more
openaire   +4 more sources

The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. [PDF]

PLoS Genetics, 2012
Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. A key function in this process involves the regulation of the cell cycle and stress responses including free radical scavenging.
Spike D L Postnikoff, Mackenzie E Malo, Berchman Wong, Troy A A Harkness   +3 more
doaj   +1 more source