Results 31 to 40 of about 94,249 (285)
Molecular Cancer, 2019 Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression
Paul Laissue
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Cell Regeneration, 2021 Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear.
Meijun Fu +15 more
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Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]
, 2015 The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya +10 more
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Cell Reports, 2021 Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity.
Benjamin Bourgeois +9 more
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Modelling the evolution of transcription factor binding preferences in complex eukaryotes [PDF]
, 2017 Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences due to their common evolutionary origin.
Caselle, Michele +3 more
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The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Molecules, 2009 Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology ...
Zhao Zhong Chong +3 more
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Ocular forkhead transcription factors: seeing eye to eye [PDF]
The International Journal of Developmental Biology, 2009 Forkhead transcription factors comprise a large family of proteins with diverse functions during development. Recently, there has been accumulating evidence that several members of this family of proteins play an important role in the development of the vertebrate retina.
Holly E, Moose +3 more
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FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Current Research in Structural Biology, 2022 Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families.
Emil Spreitzer +8 more
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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation [PDF]
Developmental Cell, 2003 An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion.
Nakae, Jun +5 more
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FoxO Proteins in the Nervous System
Analytical Cellular Pathology, 2015 Acute as well as chronic disorders of the nervous system lead to significant morbidity and mortality for millions of individuals globally. Given the ability to govern stem cell proliferation and differentiated cell survival, mammalian forkhead ...
Kenneth Maiese
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