Results 31 to 40 of about 2,538 (255)
FoxO Proteins in the Nervous System
Analytical Cellular Pathology, 2015 Acute as well as chronic disorders of the nervous system lead to significant morbidity and mortality for millions of individuals globally. Given the ability to govern stem cell proliferation and differentiated cell survival, mammalian forkhead ...
Kenneth Maiese
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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation [PDF]
Developmental Cell, 2003 An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion.
Nakae, Jun +5 more
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Analysis of the transcriptional program of developing induced regulatory T cells. [PDF]
, 2011 CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we performed
Lipsky, Peter E. +8 more
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FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Current Research in Structural Biology, 2022 Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families.
Emil Spreitzer +8 more
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Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Cells, 2019 Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang +4 more
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The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors
Cells, 2023 Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore +2 more
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Journal of the Pakistan Medical AssociationThe current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
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Biomolecules, 2019 The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.
Lukáš Slavata +13 more
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Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
npj Systems Biology and Applications, 2021 In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis
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Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics
Cells, 2019 FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...
Katarina Psenakova +5 more
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