Results 31 to 40 of about 61,376 (247)

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation [PDF]

Developmental Cell, 2003
An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion.
Nakae, Jun, Kitamura, Tadahiro, Kitamura, Yukari, Biggs, William H., Arden, Karen C., Accili, Domenico   +5 more
openaire   +2 more sources

FOXO transcription factors differ in their dynamics and intra/intermolecular interactions

Current Research in Structural Biology, 2022
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families.
Emil Spreitzer, T. Reid Alderson, Benjamin Bourgeois, Loretta Eggenreich, Hermann Habacher, Greta Bramerdorfer, Iva Pritišanac, Pedro A. Sánchez-Murcia, Tobias Madl   +8 more
doaj   +1 more source

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Cells, 2023
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore, Lilia Gheghiani, Zheng Fu   +2 more
doaj   +1 more source

Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence

Journal of the Pakistan Medical Association
The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

Biomolecules, 2019
The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.
Lukáš Slavata, Josef Chmelík, Daniel Kavan, Růžena Filandrová, Jan Fiala, Michal Rosůlek, Hynek Mrázek, Zdeněk Kukačka, Karel Vališ, Petr Man, Michael Miller, William McIntyre, Daniele Fabris, Petr Novák   +13 more
doaj   +1 more source

Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER

npj Systems Biology and Applications, 2021
In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis
doaj   +1 more source

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

Cells, 2019
FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...
Katarina Psenakova, Klara Kohoutova, Veronika Obsilova, Michael J. Ausserlechner, Vaclav Veverka, Tomas Obsil   +5 more
doaj   +1 more source

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt [PDF]

Journal of Biological Chemistry, 1999
The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of ...
E D, Tang, G, Nuñez, F G, Barr, K L, Guan   +3 more
openaire   +2 more sources