Results 11 to 20 of about 61,376 (247)
Mechanism of forkhead transcription factors binding to a novel palindromic DNA site [PDF]
Nucleic Acids Research, 2021 Yongheng Chen +2 more
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Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks
Computational and Structural Biotechnology Journal, 2022 Transcription factors are regulators of the cell’s genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation.
Matteo Barberis, Thierry D.G.A. Mondeel
doaj +1 more source
Forkhead transcription factors and ageing [PDF]
Oncogene, 2008 Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory model organisms. Some of the mechanisms involved show evolutionary conservation, opening the way to using simpler invertebrates to understand human ageing.
L, Partridge, J C, Brüning
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. [PDF]
PLoS Biology, 2007 Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age ...
Raja Kittappa +3 more
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npj Systems Biology and Applications, 2021 Networks of interacting molecules organize topology, amount, and timing of biological functions. Systems biology concepts required to pin down ‘network motifs’ or ‘design principles’ for time-dependent processes have been developed for the cell division ...
Matteo Barberis
doaj +1 more source
FoxP4, a novel forkhead transcription factor [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003 Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very
Teufel, Andreas +4 more
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Forkhead transcription factors in ovarian function [PDF]
Reproduction, 2011 Abstract Since the discovery of the conserved forkhead (Fkh) DNA binding domain more than 20 years ago, members of the Fkh or forkhead box (FOX) family of transcription factors have been shown to act as important regulators of numerous developmental and homeostatic processes.
Nina Henriette, Uhlenhaut +1 more
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The Role of Forkhead Box Family in Bone Metabolism and Diseases
Frontiers in Pharmacology, 2022 Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease.
Jianxiang Xu +18 more
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The forkhead transcription factor FoxY regulates Nanos [PDF]
Molecular Reproduction and Development, 2012 AbstractFoxY is a member of the forkhead transcription factor family that appeared enriched in the presumptive germ line of sea urchins (Ransick et al. Dev Biol 2002;246:132). Here, we test the hypothesis that FoxY is involved in germ line determination in this animal.
Jia L, Song, Gary M, Wessel
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Forkhead transcription factors regulate mosquito reproduction [PDF]
Insect Biochemistry and Molecular Biology, 2007 Forkhead-box (Fox) genes encode a family of transcription factors defined by a 'winged helix' DNA-binding domain. In this study we aimed to identify Fox factors that are expressed within the fat body of the yellow fever mosquito Aedes aegypti, and determine whether any of these are involved in the regulation of mosquito yolk protein gene expression ...
Immo A, Hansen +7 more
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