Results 11 to 20 of about 94,249 (285)
Mammalian SIRT1 Represses Forkhead Transcription Factors [PDF]
Cell, 2004 The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in
Motta, M. C. +8 more
openaire +6 more sources
Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. [PDF]
Nucleic Acids Res, 2021 Li J +12 more
europepmc +2 more sources
Forkhead transcription factors and ageing [PDF]
Oncogene, 2008 Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory model organisms. Some of the mechanisms involved show evolutionary conservation, opening the way to using simpler invertebrates to understand human ageing.
L, Partridge, J C, Brüning
openaire +2 more sources
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. [PDF]
PLoS Biology, 2007 Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age ...
Raja Kittappa +3 more
doaj +1 more source
npj Systems Biology and Applications, 2021 Networks of interacting molecules organize topology, amount, and timing of biological functions. Systems biology concepts required to pin down ‘network motifs’ or ‘design principles’ for time-dependent processes have been developed for the cell division ...
Matteo Barberis
doaj +1 more source
FoxP4, a novel forkhead transcription factor [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003 Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very
Andreas, Teufel +4 more
openaire +2 more sources
The Role of Forkhead Box Family in Bone Metabolism and Diseases
Frontiers in Pharmacology, 2022 Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease.
Jianxiang Xu +18 more
doaj +1 more source
Forkhead transcription factors in ovarian function [PDF]
REPRODUCTION, 2011 Since the discovery of the conserved forkhead (Fkh) DNA binding domain more than 20 years ago, members of the Fkh or forkhead box (FOX) family of transcription factors have been shown to act as important regulators of numerous developmental and homeostatic processes.
Nina Henriette, Uhlenhaut +1 more
openaire +2 more sources
Forkhead transcription factors regulate mosquito reproduction [PDF]
Insect Biochemistry and Molecular Biology, 2007 Forkhead-box (Fox) genes encode a family of transcription factors defined by a 'winged helix' DNA-binding domain. In this study we aimed to identify Fox factors that are expressed within the fat body of the yellow fever mosquito Aedes aegypti, and determine whether any of these are involved in the regulation of mosquito yolk protein gene expression ...
Immo A, Hansen +7 more
openaire +2 more sources
DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling [PDF]
, 2020 DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and ...
Braeckman, Bart, Zečić, Aleksandra
core +1 more source