Fractalkine is expressed in the human ovary and increases progesterone biosynthesis in human luteinised granulosa cells [PDF]
Reproductive Biology and Endocrinology, 2011 Background Recent evidence from rodent ovaries has demonstrated expression of fractalkine and the existence of fractalkine receptor, and showed that there is a significant increase in steroidogenesis in response to fractalkine, yet the role of ...
Yan Jie +6 more
doaj +3 more sources
Fractalkine depresses cardiomyocyte contractility. [PDF]
PLoS ONE, 2013 Our laboratory reported that male mice with cardiomyocyte-selective knockout of the prostaglandin E2 EP4 receptor sub-type (EP4 KO) exhibit reduced cardiac function.
David Taube +5 more
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Relationship Between the Degree of Diabetic Retinopathy and Serum Fractalkine (CX3CL1) in Patients with Type 2 Diabetes: A Single-Center Cross-Sectional Study [PDF]
MedicinaBackground and Objectives: Diabetic retinopathy (DR) is a leading microvascular complication of type 2 diabetes (T2D). Fractalkine (CX3CL1), a chemokine involved in inflammation, angiogenesis, and microglial activation, may play a role in DR pathogenesis.
Ozgur Yilmaz +5 more
doaj +2 more sources
Lack of Fractalkine Receptor on Macrophages Impairs Spontaneous Recovery of Ribbon Synapses After Moderate Noise Trauma in C57BL/6 Mice [PDF]
Frontiers in Neuroscience, 2019 Noise trauma causes loss of synaptic connections between cochlear inner hair cells (IHCs) and the spiral ganglion neurons (SGNs). Such synaptic loss can trigger slow and progressive degeneration of SGNs.
Tejbeer Kaur +6 more
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Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders [PDF]
Frontiers in Cellular NeuroscienceIntroductionChronic neuroinflammation is a persistent feature of individuals with Parkinson’s disease (PD). Dopaminergic neurodegeneration is partially associated with neuroinflammation.
Yaping Chu +3 more
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Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction
Gynecology Obstetrics & Reproductive Medicine, 2023 OBJECTIVE: Fractalkine is a newly discovered chemokine that is expressed in placental tissue during pregnancy and is subsequently shed into the maternal serum.
Ecem Berfun Toprak Sager +4 more
doaj +1 more source
Scientific Reports, 2022 Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia.
Namiko Kawamura +9 more
doaj +1 more source
PLoS ONE, 2017 Rhinovirus infection is associated with the majority of asthma exacerbations. The role of fractalkine in anti-viral (type 1) and pathogenic (type 2) responses to rhinovirus infection in allergic asthma is unknown.
Nadine Upton +17 more
doaj +1 more source
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]
, 2015 BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott +4 more
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The Association of Plasma Fractalkine and Inflammation After Ischemic Stroke
Indonesian Biomedical Journal, 2016 BACKGROUND: Inflammation affects the brain after stroke with main functions to rapidly eliminate the source of the disturbance, remove damaged tissue and then restore tissue homeostasis.
Lucia Herminawati +3 more
doaj +1 more source