Results 1 to 10 of about 464,323 (316)
Il-10 signaling reduces survival in mouse models of synucleinopathy
npj Parkinson's Disease, 2021 Parkinson’s disease (PD) and related synucleinopathies are characterized by chronic neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate synucleinopathy and associated sequelae. To test this idea, we used recombinant
Samuel G. Cockey +12 more
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Acta Neuropathologica Communications, 2023 Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging.
Tristan Williams +10 more
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Aquaporins and Neurodegenerative Diseases [PDF]
Current Neuropharmacology, 2010 Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
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Epilepsy in neurodegenerative diseases
Epileptic Disorders, 2022 AbstractAlthough epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined. Improved health care, resulting in increased longevity, will unavoidably lead to an increment of epilepsy cases ...
Neri, Sabrina +4 more
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Mitoepigenetics and Neurodegenerative Diseases [PDF]
Frontiers in Endocrinology, 2019 Mitochondrial impairment and increased oxidative stress are common features in neurodegenerative disorders, leading researchers to speculate that epigenetic changes in the mitochondrial DNA (mitoepigenetics) could contribute to neurodegeneration.
Coppede F., Stoccoro A.
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Advances in Neurodegenerative Diseases
Neurology International, 2022 A multitude of diseases presenting a wide variety of phenotypic appearances are included in neurodegenerative disorders [...]
Vasileios Siokas, Efthimios Dardiotis
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Impact of APOE genotype on prion-type propagation of tauopathy
Acta Neuropathologica Communications, 2022 Apolipoprotein (APOE) is a major risk factor of Alzheimer’s disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau.
Tristan Williams +10 more
doaj +1 more source
Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets
Journal of Hematology & Oncology, 2021 Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate ...
Sung-Hyun Kim +3 more
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Alzheimer’s Research & Therapy, 2022 Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of ...
Andrea Arighi +12 more
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Biomarkers in Neurodegenerative Diseases [PDF]
Biomedicines, 2022 An increasing number of people are affected by various neurodegenerative diseases each year, impacting the quality of life of millions of people worldwide [...]
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