Results 1 to 10 of about 393,239 (119)

Il-10 signaling reduces survival in mouse models of synucleinopathy

npj Parkinson's Disease, 2021
Parkinson’s disease (PD) and related synucleinopathies are characterized by chronic neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate synucleinopathy and associated sequelae. To test this idea, we used recombinant
Samuel G. Cockey, Karen N. McFarland, Emily J. Koller, Mieu M. T. Brooks, Elsa Gonzalez De La Cruz, Pedro E. Cruz, Carolina Ceballos-Diaz, Awilda M. Rosario, Yona R. Levites, David R. Borchelt, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty   +12 more
doaj   +1 more source

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy

Acta Neuropathologica Communications, 2023
Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging.
Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P. Hery, Patrick Sullivan, David R. Borchelt, Stefan Prokop, Paramita Chakrabarty   +10 more
doaj   +1 more source

Impact of APOE genotype on prion-type propagation of tauopathy

Acta Neuropathologica Communications, 2022
Apolipoprotein (APOE) is a major risk factor of Alzheimer’s disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau.
Tristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Guilian Xu, Karen McFarland, Benoit I. Giasson, Patrick Sullivan, David R. Borchelt, Paramita Chakrabarty   +10 more
doaj   +1 more source

Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets

Journal of Hematology & Oncology, 2021
Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate ...
Sung-Hyun Kim, Key-Hwan Lim, Sumin Yang, Jae-Yeol Joo   +3 more
doaj   +1 more source

Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Michael R. Strickland, Kristen R. Ibanez, Mariya Yaroshenko, Carolina Ceballos Diaz, David R. Borchelt, Paramita Chakrabarty   +5 more
doaj   +1 more source

A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

Molecular Neurodegeneration, 2021
Background There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau.
Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn Grace Johnson, James A. Webster, Rhythm Shah, Duc Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. Stein, Ann C. McKee, Chadwick M. Hales   +11 more
doaj   +1 more source

Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

Alzheimer’s Research & Therapy, 2022
Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of ...
Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini, Daniela Galimberti   +12 more
doaj   +1 more source

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Acta Neuropathologica Communications, 2023
Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer’s disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights
Ethan D. Smith, Quan Vo, Benoit I. Giasson, David R. Borchelt, Stefan Prokop, Paramita Chakrabarty   +5 more
doaj   +1 more source

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

Acta Neuropathologica Communications, 2018
Mutations in MATR3 have been associated with amyotrophic lateral sclerosis (ALS) as well as a form of distal myopathy termed vocal cord pharyngeal distal myopathy (VCPDM).
Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, David R. Borchelt, Jada Lewis   +11 more
doaj   +1 more source

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

Acta Neuropathologica Communications, 2017
The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation ...
Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, Maurice S. Swanson, Lucia Notterpek, David R. Borchelt, Jada Lewis   +13 more
doaj   +1 more source