Results 11 to 20 of about 464,323 (316)
Molecular Neurodegeneration, 2021 Background There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau.
Laura Gutierrez-Quiceno +11 more
doaj +1 more source
Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Michael R. Strickland +5 more
doaj +1 more source
Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Acta Neuropathologica Communications, 2023 Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer’s disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights
Ethan D. Smith +5 more
doaj +1 more source
TREM2 in Neurodegenerative Diseases [PDF]
Molecular Neurodegeneration, 2017 TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these variants conclusively demonstrates that the immune response can play an active role in the pathogenesis of NDDs.
Jay, Taylor R. +2 more
openaire +3 more sources
Acta Neuropathologica Communications, 2018 Mutations in MATR3 have been associated with amyotrophic lateral sclerosis (ALS) as well as a form of distal myopathy termed vocal cord pharyngeal distal myopathy (VCPDM).
Christina Moloney +11 more
doaj +1 more source
The lysosome and neurodegenerative diseases [PDF]
Acta Biochimica et Biophysica Sinica, 2009 It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Lisha, Zhang, Rui, Sheng, Zhenghong, Qin
openaire +2 more sources
The role of iron in neurodegenerative disorders : insights and opportunities with synchrotron light [PDF]
, 2014 There is evidence for iron dysregulation in many forms of disease, including a broad spectrum of neurodegenerative disorders. In order to advance our understanding of the pathophysiological role of iron, it is helpful to be able to determine in detail ...
Mark R. Davidson +3 more
core +1 more source
Acta Neuropathologica Communications, 2017 The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express human MATR3 containing the F115C mutation ...
Christina Moloney +13 more
doaj +1 more source
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Alzheimer’s Research & Therapy, 2022 Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis.
Kristen R. Ibanez +16 more
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L. +1 more
core +1 more source