Results 11 to 20 of about 5,310,608 (313)
Proteotoxicity and Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2020 Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions.
Ruz, Clara +4 more
openaire +2 more sources
Aquaporins and Neurodegenerative Diseases [PDF]
Current Neuropharmacology, 2010 Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
openaire +2 more sources
Mitoepigenetics and Neurodegenerative Diseases [PDF]
Frontiers in Endocrinology, 2019 Mitochondrial impairment and increased oxidative stress are common features in neurodegenerative disorders, leading researchers to speculate that epigenetic changes in the mitochondrial DNA (mitoepigenetics) could contribute to neurodegeneration.
Coppede F., Stoccoro A.
openaire +3 more sources
Neuregulins in Neurodegenerative Diseases [PDF]
Frontiers in Aging Neuroscience, 2021 Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions.
Guan-yong Ou +3 more
openaire +3 more sources
Microglia in neurodegenerative diseases
Neural Regeneration Research, 2020 A major feature of neurodegeneration is disruption of central nervous system homeostasis, during which microglia play diverse roles. In the central nervous system, microglia serve as the first line of immune defense and function in synapse pruning, injury repair, homeostasis maintenance, and regulation of brain development through scavenging and ...
Yu Xu +3 more
openaire +3 more sources
The role of iron in neurodegenerative disorders : insights and opportunities with synchrotron light [PDF]
, 2014 There is evidence for iron dysregulation in many forms of disease, including a broad spectrum of neurodegenerative disorders. In order to advance our understanding of the pathophysiological role of iron, it is helpful to be able to determine in detail ...
Mark R. Davidson +3 more
core +1 more source
Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
Alzheimer’s Research & Therapy, 2022 Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis.
Kristen R. Ibanez +16 more
doaj +1 more source
Synapses in neurodegenerative diseases [PDF]
BMB Reports, 2017 Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow.
Bae, Jae Ryul, Kim, Sung Hyun
openaire +2 more sources
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L. +1 more
core +1 more source
Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case
Acta Neuropathologica Communications, 2017 [F-18]-AV-1451 is a novel positron emission tomography (PET) tracer with high affinity to neurofibrillary tau pathology in Alzheimer’s disease (AD). PET studies have shown increased tracer retention in patients clinically diagnosed with dementia of AD ...
Marta Marquié +15 more
doaj +1 more source