Results 31 to 40 of about 5,310,608 (313)
Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. [PDF]
, 2010 The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of ...
Handley, Olivia J +59 more
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Nature Communications, 2021 Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.
Zhongbo Chen +13 more
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Mushroom Natural Products in Neurodegenerative Disease Drug Discovery
, 2022 The variety of drugs available to treat neurodegenerative diseases is limited. Most of these drug’s efficacy is restricted by individual genetics and disease stages and usually do not prevent neurodegeneration acting long after irreversible damage has ...
Evelin Tiralongo +7 more
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Acta Neuropathologica Communications, 2023 Extracellular amyloid-β (Aβ) plaques and intracellular aggregates of tau protein in form of neurofibrillary tangles (NFT) are pathological hallmarks of Alzheimer’s disease (AD). The exact mechanism how these two protein aggregates interact in AD is still
Wangchen Tsering +7 more
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Huntington's disease: An immune perspective [PDF]
, 2011 Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Kishore, U +9 more
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Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]
, 2001 Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Skutella, T. +7 more
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Neurodegenerative diseases: challenges [PDF]
Drug Delivery and Translational Research, 2011 Diseases of the aging brain—including Alzheimer’s, Parkinson’s, and Huntington’s—affect the lives of millions and pose a growing threat to public health. These diseases occur as a result of neurodegenerative processes involving the progressive loss of structure or function of neurons, including death of neurons.
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The lysosome and neurodegenerative diseases [PDF]
Acta Biochimica et Biophysica Sinica, 2009 It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Lisha, Zhang, Rui, Sheng, Zhenghong, Qin
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Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile +70 more
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BMC Biology, 2018 Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria.
Ziyun Wu +10 more
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