Results 51 to 60 of about 464,323 (316)

Modification of Hospitalization Risk by Gender and Dementia Status Between the Ages of 85 and 95 in a German Cohort Based on Health Claims Data

BMC Health Services Research
Background Hospitalizations among older adults differ by dementia status, gender, and living arrangements. Understanding these differences, particularly in advanced age (age 85 and above), can inform appropriate healthcare strategies.
Gabriele Doblhammer, Elena Rakuša, Anne Fink   +2 more
doaj   +1 more source

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

Scientific Reports, 2018
The Hippo signaling pathway is involved in organ size regulation and tumor suppression. Although inhibition of Hippo leads to tumorigenesis, activation of Hippo may play a role in neurodegeneration.
Kaly A. Mueller, Kelly E. Glajch, Megan N. Huizenga, Remi A. Wilson, Eric J. Granucci, Amanda M. Dios, Adelaide R. Tousley, Maria Iuliano, Elizabeth Weisman, Michael J. LaQuaglia, Marian DiFiglia, Kimberly Kegel-Gleason, Khashayar Vakili, Ghazaleh Sadri-Vakili   +13 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]

, 2008
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen, Bezprozvanny, I, Nelson, O, Hammer, R, Tu, H, Nukina, N, O. Nelson, N. Nukina, Chen, X, Tang, TS, T.-S. Tang, Pook, M, H. Tu, R. Hammer, I. Bezprozvanny, M. Pook   +15 more
core   +1 more source

Impaired Interoceptive Accuracy in Semantic Variant Primary Progressive Aphasia

Frontiers in Neurology, 2017
BackgroundInteroception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects.
Charles R. Marshall, Charles R. Marshall, Chris J. D. Hardy, Lucy L. Russell, Camilla N. Clark, Katrina M. Dick, Emilie V. Brotherhood, Rebecca L. Bond, Catherine J. Mummery, Jonathan M. Schott, Jonathan D. Rohrer, James M. Kilner, Jason D. Warren   +12 more
doaj   +1 more source

Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

Journal of Neuroinflammation, 2021
Background Neuroinflammation may contribute to the pathogenesis of Huntington’s disease, given evidence of activated microglia and elevated levels of inflammatory molecules in disease gene carriers, even those many years from symptom onset. We have shown
Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph Andre   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Pharmacotherapy of Neurodegenerative Diseases

, 2022
Amyotrophic Lateral Sclerosis (ALS) is a fatal idiopathic neurodegenerative disease that is characterized by degeneration of both upper and lower motor neurons. ALS currently only has 2 drugs approved as disease modyfying, whereas the rest of the therapy
Adem, Muna Abdu
core  

Memory in Neurodegenerative Disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1999
Memory in Neurodegenerative Disease . Edited by alexander i troster. (Pp 413, £60.00 (US $95.00). Published by Cambridge University Press, Cambridge 1998. ISBN 0-521-57192-8. No one can doubt the increasing importance, to affected families and the healthcare system, of Alzheimer’s disease, Parkinson’s disease, and the other degenerative conditions of ...
openaire   +2 more sources

Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer’s disease

Alzheimer’s Research & Therapy, 2018
Background Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias. Methods
Chris J. D. Hardy, Charles R. Marshall, Rebecca L. Bond, Lucy L. Russell, Katrina Dick, Cono Ariti, David L. Thomas, Sonya J. Ross, Jennifer L. Agustus, Sebastian J. Crutch, Jonathan D. Rohrer, Doris-Eva Bamiou, Jason D. Warren   +12 more
doaj   +1 more source