Results 21 to 30 of about 5,310,608 (313)

Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease

Scientific Reports, 2022
The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far, failed to improve symptoms in AD.
Heng Zhou, Hanyan Li, Niket Gowravaram, Moqin Quan, Naila Kausar, Stephen N. Gomperts   +5 more
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Neuronal SNCA transcription during Lewy body formation

Acta Neuropathologica Communications, 2023
Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs   +8 more
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Hallucinations in Neurodegenerative Diseases [PDF]

CNS Neuroscience & Therapeutics, 2011
SUMMARYPatients with neurodegenerative disease frequently experience hallucinations and illusionary perceptions. As early symptoms, hallucinations may even have diagnostic relevance (i.e., for the diagnosis of Lewy Body Dementia). In the later course of the disease, hallucinations may appear as characteristic symptoms and often constitute a particular ...
Lothar, Burghaus, Carsten, Eggers, Lars, Timmermann, Gereon R, Fink, Nico J, Diederich   +4 more
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Hallmarks of neurodegenerative diseases

Cell, 2023
Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA ...
Wilson III, David M., Cookson, Mark R., Van Den Bosch, Ludo, Zetterberg, Henrik, Holtzman, David M., Dewachter, Ilse   +5 more
openaire   +5 more sources

Variation within the Huntington's disease gene influences normal brain structure. [PDF]

, 2011
Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we
Juliane Winkelmann, Meisenzahl Eva M., Rujescu Dan, Rujescu, D., Giegling Ina, Gaser, C., Mühlau Mark, Eva M. Meisenzahl, Giegling, Ina, Winkelmann, Juliane, Winkelmann Juliane, Dan Rujescu, Meisenzahl, E.M., Adolph Weindl, Reiser Maximilian, Ina Giegling, Arsic, M., Winkelmann, J., Meisenzahl, Eva M., Koutsouleris Nikolaos, Gaser, Christian, Koutsouleris, Nikolaos, Christian Gaser, Reiser, M., Reiser, Maximilian, Gaser Christian, Mühlau, Mark, Giegling, I., Nikolaos Koutsouleris, Weindl Adolph, Mühlau, M., Arsic Milan, Mark Mühlau, Maximilian Reiser, Milan Arsic, Koutsouleris, N., Weindl, A., Weindl, Adolph, Eva M Meisenzahl, Arsic, Milan, Rujescu, Dan   +40 more
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Brainstem : neglected locus in neurodegenerative diseases [PDF]

, 2011
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP).
Lea Tenenholz Grinberg, Lea T Grinberg, Helmut Heinsen, Udo eRueb, Udo Rueb, Tenenholz Grinberg, Lea, Heinsen, Helmut, Rüb, Udo, Helmut eHeinsen   +8 more
core   +1 more source

Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis

Acta Neuropathologica Communications, 2022
In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for the loss of their more disease-susceptible counterparts.
Seong Kwon Hur, Mandana Hunter, Myrna A. Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q. Trojanowski, Krista J. Spiller, Virginia M.-Y. Lee   +8 more
doaj   +1 more source

The cytoskeleton in neurodegenerative diseases [PDF]

The Journal of Pathology, 2004
AbstractAbundant abnormal aggregates of cytoskeletal proteins are neuropathological signatures of many neurodegenerative diseases that are broadly classified by filamentous aggregates of neuronal intermediate filament (IF) proteins, or by inclusions containing the microtubule‐associated protein (MAP) tau.
Nigel J, Cairns, Virginia M-Y, Lee, John Q, Trojanowski   +2 more
openaire   +2 more sources

Pros and cons of a prion-like pathogenesis in Parkinson's disease [PDF]

, 2011
Background: Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex.
Chapman Joab, Hilker, Ruediger, Brotchie, Jonathan M, Hilker, Rüdiger, Hilker Ruediger, Brotchie, Jonathan M., Joab Chapman, Ruediger Hilker, Chapman, Joab, Jonathan M Brotchie, Brotchie Jonathan M   +10 more
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Sex Differences in Stroke Subtypes, Severity, Risk Factors, and Outcomes Among Elderly Patients with Acute Ischemic Stroke

Frontiers in Aging Neuroscience, 2015
Background: Although the age-specific incidence and mortality of stroke is higher among men, stroke has a greater clinical effect on women. However, the sex differences in stroke among elderly patients are unknown.
Changshen eYu, Zhongping eAn, Wenjuan eZhao, Wanjun eWang, Chunlin eGao, Shoufeng eLiu, Jinghua eWang, Jialing eWu   +7 more
doaj   +1 more source