Results 21 to 30 of about 636,708 (294)
Scientific Reports, 2022 The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far, failed to improve symptoms in AD.
Heng Zhou +5 more
doaj +1 more source
Neuronal SNCA transcription during Lewy body formation
Acta Neuropathologica Communications, 2023 Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’
Tomoya Kon +8 more
doaj +1 more source
Viral-induced neurodegenerative disease. [PDF]
, 1999 Viral etiology has been postulated in a variety of neurological diseases in humans, including multiple sclerosis. Several experimental animal models of viral-induced neurodegenerative disease provide insight into potential host- and pathogen-dependent ...
Buchmeier, MJ, Lane, TE
core +1 more source
Frontiers in Aging Neuroscience, 2015 Background: Although the age-specific incidence and mortality of stroke is higher among men, stroke has a greater clinical effect on women. However, the sex differences in stroke among elderly patients are unknown.
Changshen eYu +7 more
doaj +1 more source
Acta Neuropathologica Communications, 2022 In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for the loss of their more disease-susceptible counterparts.
Seong Kwon Hur +8 more
doaj +1 more source
The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases [PDF]
, 2014 Copyright © 2014 Al-Mahdawi, Anjomani Virmouni and Pook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Al-Mahdawi, S, Pook, MA, Virmouni, SA
core +1 more source
Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]
, 2010 Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai +4 more
core +1 more source
Nature Communications, 2021 Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.
Zhongbo Chen +13 more
doaj +1 more source
Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease [PDF]
, 2015 Many different environmental factors (nutrients, pollutants, chemicals, physical activity, lifestyle, physical and mental stress) can modulate epigenetic markers in the developing and adult organism. Epigenetics, in turn, can cause and is associated with
FUSO, ANDREA +2 more
core +3 more sources
Neurodegeneration: Potential Causes, Prevention, and Future Treatment Options [PDF]
, 2011 Here I advance a hypothesis that neurodegeneration is a natural process associated with aging due to the loss of genetic redundancy following a mathematical model R(t) = R0(1-αe(βC+γI+δEt)t), where the calorie intake (C) and ...
Zhongtao Zhang
core +2 more sources