Results 91 to 100 of about 20,377 (204)

Rosiglitazone activation of PPARγ suppresses fractalkine signaling [PDF]

Journal of Molecular Endocrinology, 2009
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARγ is accentuated by the widespread use of synthetic PPARγ agonists, thiazolidinediones (such as rosiglitazone), as drugs for insulin resistance and type II diabetes.
Wan, Yihong, Evans, Ronald M
openaire   +2 more sources

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

The Association Between Irritable Bowel Syndrome and Generalized Anxiety Disorder and Influencing Factors: A Mediation Mendelian Randomization Study

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Based on Mendelian randomization analysis, this study established a significant causal effect of irritable bowel syndrome (IBS) on increasing generalized anxiety disorder (GAD) risk (odds ratio = 1.328; p < 0.001) and identified dozens of gut microbial taxa, plasma metabolites, inflammatory factors, and immune cell characteristics with potential causal
Weili Yang, Yongxi Wang, Shasha Wang, Hongbing Zhai, Jun Che, Xin Wang, Yafeng Yang, Zebo Jia   +7 more
wiley   +1 more source

Low-dose prenatal alcohol exposure modulates weight gain and eliminates fractalkine expression in e14.5 mouse embryos [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2017
Fetal Alcohol Spectrum Disorder (FASD) is caused by maternal alcohol consumption during pregnancy and often leads to long-lasting developmental symptoms, including increased microglial migration and increased release of the chemokine, fractalkine, both ...
Jordyn Karliner, Mark Nagy, Joyce Sanya, Noah Yeagley, Zoe Barnett-Ohori, Lauren D’Ortona, Jill Lawrence, R. Colin McNamara, Rachel Boas, Heather Brubaker, Spencer Collopy, Justin Nolan, Carlita Favero   +12 more
doaj  

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration [PDF]

, 2012
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing secondary necrosis and release of pro-inflammatory intracellular components.
Jonas J. Neher, Urte Neniskyte, Guy C. Brown   +2 more
core   +2 more sources

Cerebrospinal Fluid Biomarkers of NLRP3 Pathway, Immune Dysregulation, and Neurodegeneration in Parkinson's Disease: A Meta‐Analysis

Movement Disorders, Volume 41, Issue 2, Page 466-477, February 2026.
Abstract Background The activation of the NOD‐, LRR‐ and pyrin domain‐containing protein 3 (NLRP3) inflammasome and associated immune dysregulation is one of the key pathological processes preceding and accompanying α‐synuclein pathology, neuronal damage, and cell death in Parkinson's disease (PD).
Alina‐Măriuca Marinescu, Venissa Machado, Gennaro Pagano, Nicoletta Milani Muelhardt, Thomas Kustermann, Eva Zsuzsanna Mracsko, Kathrin Brockmann, Nima Shariati, Judith Anzures‐Cabrera, Bastian Zinnhardt   +9 more
wiley   +1 more source

Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects

Vascular Health and Risk Management, 2009
Lars Maegdefessel1,3, Axel Schlitt1, Susanna Pippig1, Bernhard Schwaab2, Kerstin Fingscheidt2, Uwe Raaz1, Michael Buerke1, Harald Loppnow11Universit&auml;tsklinik und Poliklinik f&uuml;r Innere Medizin III, Martin-Luther-Universit&auml;t ...
Lars Maegdefessel, Axel Schlitt, Susanna Pippig, et al   +3 more
doaj  

Clinical and diagnostic value of the determinantion of fractalkine in atopic dermatitis in children

RUDN Journal of Medicine, 2018
Atopic dermatitis belongs to the most common dermatoses observed in practice. In 2016 it was in 647 cases of atopic dermatitis (439,2 per 100 thousand population), while the main group of cases were children aged 0 to 14 years (64%). Aim.
M M Ben, E Ya Yanchevskaya, O A Mesnyankina   +2 more
doaj   +1 more source

Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA [PDF]

, 2017
Introduction: The epithelial and endothelial barriers of the airway mucosa are critical for regulation of tissue homeostasis and protection against pathogens or other tissue damaging agents.
Ahn, Armuzzi, Bartczak, Bengalli, Berry, Blandizzi, Blume, Blume, Blume, Chowdhury, Davies, Dimasi, Gehr, Gupta, Hardyman, Hartnett, Holgate, Holmes, Howarth, Huh, Huh, Julia, Kasper, Laviola, Lora, Loxham, Marcos-Ramiro, Matsumiya, Miller, Neuhaus, Ning, Pober, Rezaee, Rimaniol, Ritter, Schraufstatter, Sisler, Snyder-Talkington, Unger, Voisin, Wang, Wang, White, Woodside, Zhang   +44 more
core   +1 more source

Fractalkine in Health and Disease

International Journal of Molecular Sciences
CX3CL1 is one of the 50 up-to-date identified and characterized chemokines. While other chemokines are produced as small, secreted proteins, CX3CL1 (fractalkine) is synthetized as a transmembrane protein which also leads to a soluble form produced as a result of proteolytic cleavage.
Claudia Rodriguez, Luisa Chocarro, Miriam Echaide, Karina Ausin, David Escors, Grazyna Kochan   +5 more
openaire   +2 more sources