Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation. [PDF]
Glia– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Hammond BP +4 more
europepmc +2 more sources
Fractalkine/CX3CL1 in Neoplastic Processes [PDF]
International Journal of Molecular Sciences, 2020 Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes—mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma ...
Jan Korbecki +6 more
openaire +2 more sources
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina [PDF]
, 2017 Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable neurons.
Byrne, Ashleigh M. +4 more
core +9 more sources
Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis
Frontiers in Cellular Neuroscience, 2014 Apoptotic neurons generated during normal brain development or secondary to pathologic insults are efficiently cleared from the central nervous system.
Jennifer D Sokolowski +5 more
doaj +1 more source
Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient. [PDF]
, 2016 BACKGROUND: Adoptive T-cell based immunotherapies constitute a promising approach to treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor responses.
Allavena, P. +4 more
core +9 more sources
Soluble fractalkine in the plasma of fibromyalgia patients
Anais da Academia Brasileira de Ciências, 2014 Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease.
JUAN J. GARCIA, EDUARDO ORTEGA
doaj +1 more source
Development of Fractalkine-Targeted Nanofibers that Localize to Sites of Arterial Injury
Nanomaterials, 2020 Atherosclerosis is the leading cause of death and disability around the world, with current treatments limited by neointimal hyperplasia. Our goal was to synthesize, characterize, and evaluate an injectable, targeted nanomaterial that will specifically ...
Hussein A. Kassam +6 more
doaj +1 more source
IBRO Reports, 2020 Patients with diabetes mellitus are predisposed to cognitive impairment. Fractalkine-CX3CR1 in the brain signaling represents a primary neuron-microglia inter-regulatory system for several brain functions including learning and memory processes.
Namiko Kawamura +5 more
doaj +1 more source