Results 21 to 30 of about 20,377 (204)

Role of fractalkine/CX3CR1 interaction in light-induced photoreceptor degeneration through regulating retinal microglial activation and migration. [PDF]

PLoS ONE, 2012
BACKGROUND: Excessive exposure to light enhances the progression and severity of some human retinal degenerative diseases. While retinal microglia are likely to be important in neuron damage associated with these diseases, the relationship between ...
Meng Zhang, Gezhi Xu, Wei Liu, Yingqin Ni, Wenting Zhou   +4 more
doaj   +1 more source

Inflammation as a Central Mechanism in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles.
Bemiller, Shane M., Kinney, Jefferson W., Lamb, Bruce T., Leisgang, Amanda M., Murtishaw, Andrew S., Salazar, Arnold M.   +5 more
core   +2 more sources

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB

Mediators of Inflammation, 2017
Background. LBP and fractalkine are known to be involved in the pathogenesis of ARDS. This study investigated the relationship between LBP and fractalkine in LPS-induced A549 cells and rat lung tissue in an ARDS rat model. Methods.
Xia Huang, Yi Zeng, Yujie Jiang, Yueqiu Qin, Weigui Luo, Shulin Xiang, Suren R. Sooranna, Liao Pinhu   +7 more
doaj   +1 more source

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1 [PDF]

, 2018
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the
Araque, Pedronel, Cardona, Astrid E., Cardona, Sandra M., Church, Kaira A., Cleary, Ian A., Kim, Sangwon V., Mendiola, Andrew S., Parker-Thornburg, Jan, Ransohoff, Richard M., Saville, Stephen P., Soto-Ospina, Alejandro, Torres, Vanessa O., Watowich, Stephanie S.   +12 more
core   +3 more sources

Fractalkine/CX₃CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death

Molecular Neurodegeneration, 2011
Background Fractalkine/CX3CL1 and its cognate receptor CX3CR1 are abundantly expressed in the CNS. Fractalkine is an unusual C-X3-C motif chemokine that is important in neuron-microglial communication, a co-receptor for HIV infection, and can be ...
Suzuki Masami, El-Hage Nazira, Zou Shiping, Hahn Yun-Kyung, Sorrell Mary E, Sturgill Jamie L, Conrad Daniel H, Knapp Pamela E, Hauser Kurt F   +8 more
doaj   +1 more source

Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain [PDF]

, 2018
The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce neuroblasts throughout life.
Pastor Loro, Ángel Manuel, Rodríguez Matarredona, Esperanza, Talaverón Aguilocho, Rocío   +2 more
core   +1 more source

Impaired brain fractalkine-CX3CR1 signaling is implicated in cognitive dysfunction in diet-induced obese mice

BMJ Open Diabetes Research & Care, 2021
Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the
Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Ela Novianti, Akio Inui, Akihiro Asakawa   +5 more
doaj   +1 more source

CX3CR1 Polymorphisms are associated with atopy but not asthma in German children [PDF]

, 2007
Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation.
Christian Vogelberg, Christophe Combadière, Combadiere C, Daoudi M, Davis CN, Erika von Mutius, Fraticelli P, Fujimoto K, Kormann MS, Laprise C, Martin Depner, Michael Kabesch, Michael S.D. Kormann, Moatti D, Niess JH, Norman Klopp, Rimaniol AC, Simpson A, Stephan K. Weiland, Thomas Illig, Tremblay K   +20 more
core   +2 more sources

The glia-immune network: Astrocytes and oligodendrocytes as microglial co-ordinators in health and disease. [PDF]

J Physiol
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Mitchener VFT, Thackray MJ, Arancibia-Cárcamo IL.   +2 more
europepmc   +2 more sources

Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]

, 2019
Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux, Bollinger, Cantaut-Belarif, Constantine-Paton, Conti, De Biase, Dobrunz, Doorn, Dumas, Durand, Durand, Gasparini, Gosselin, Grabert, Hellwig, Hessler, Hoshiko, Hsia, Isaac, Khazipov, Korber, Kullmann, Lam, Lavin, Limatola, Lowery, Maggi, Milior, Miyamoto, Mosser, Nimmerjahn, Pagani, Paolicelli, Paolicelli, Parkhurst, Pascual, Pfeiffer, Piccinin, Ragozzino, Renger, Reshef, Reshef, Ricci-Tersenghi, Sallert, Santello, Schafer, Schecter, Sellner, Semple, Singh, Stevens, Tian, Tremblay, Tremblay, Voronin, Wake, Wasling, Weinhard, Winkler, Wolf, Yoon, Zhan   +61 more
core   +1 more source