Results 71 to 80 of about 20,377 (204)

CX3CL1/Fractalkine: A Potential Biomarker for Liver Fibrosis in Chronic HBV Infection

Current Issues in Molecular Biology
A hepatitis B virus (HBV) infection can progress to chronic hepatitis, leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. CX3CL1/Fractalkine plays a crucial role in recruiting immune cells that are responsible for protecting against HBV ...
Natalia A. Arsentieva, Zoia R. Korobova, Oleg K. Batsunov, Natalia E. Lyubimova, Valentina V. Basina, Elena V. Esaulenko, Areg A. Totolian   +6 more
doaj   +1 more source

Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients

Frontiers in Immunology, 2018
The omentum is enriched with pro-inflammatory effector memory CD8+ T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma (EAC) and we have identified the chemokine macrophage inflammatory protein-1alpha as a key ...
Melissa J. Conroy, Stephen G. Maher, Ashanty M. Melo, Suzanne L. Doyle, Emma Foley, John V. Reynolds, John V. Reynolds, Aideen Long, Joanne Lysaght   +8 more
doaj   +1 more source

Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism [PDF]

Brazilian Journal of Medical and Biological Research, 2014
Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris ...
Z.X. Zhong, B. Li, C.R. Li, Q.F. Zhang, Z.D. Liu, P.F. Zhang, X.F. Gu, H. Luo, M.J. Li, H.S. Luo, G.H. Ye, F.L. Wen   +11 more
doaj   +1 more source

Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]

, 2020
BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U., Byvaltcev, Egor, Döhne, Noah, Grosser, Sabine, Janach, Gabriel M. S., Reetz, Olivia, Stadler, Konstantin, Strauss, Ulf   +7 more
core   +1 more source

Fractalkine: one chemokine, many functions

Blood, 2009
CX3CL1 (Fractalkine) is an atypical chemokine with a documented role in the development of numerous inflammatory diseases including atherosclerosis. In this issue of Blood , Landsman and colleagues demonstrate that interactions between CX3CL1 and its receptor CX3CR1 are involved in monocyte ...
White, G, Greaves, D
openaire   +3 more sources

Defective microglial development in the hippocampus of Cx3cr1 deficient mice

Frontiers in Cellular Neuroscience, 2015
Microglial cells participate in brain development and influence neuronal loss and synaptic maturation. Fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the ...
Francesca ePagani, Rosa ePaolicelli, Rosa ePaolicelli, Emanuele eMurana, Barbara eCortese, Silvia eDi Angelantonio, Silvia eDi Angelantonio, Emanuele eZurolo, Eva eGuiducci, Tiago A. eFerreira, Stefano eGarofalo, Myriam eCatalano, Myriam eCatalano, Giuseppina eD'Alessandro, Alessandra ePorzia, Giovanna ePeruzzi, Fabrizio eMainiero, Cristina eLimatola, Cristina eLimatola, Cornelius eGross, Davide eRagozzino, Davide eRagozzino   +21 more
doaj   +1 more source

Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder

Biomedicines, 2022
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its ...
Nerea Requena-Ocaña, María Flores-Lopez, Esther Papaseit, Nuria García-Marchena, Juan Jesús Ruiz, Jesús Ortega-Pinazo, Antonia Serrano, Francisco Javier Pavón-Morón, Magí Farré, Juan Suarez, Fernando Rodríguez de Fonseca, Pedro Araos   +11 more
doaj   +1 more source

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

Fractalkine in Vascular Biology [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Fractalkine (now also called CX3CL1) is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-γ and tumor necrosis factor-α.
Hisanori, Umehara, Eda T, Bloom, Toshiro, Okazaki, Yutaka, Nagano, Osamu, Yoshie, Toshio, Imai   +5 more
openaire   +2 more sources

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source