Results 111 to 120 of about 39,478 (331)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Fractional Definite Integral

open access: yesFractal and Fractional, 2017
This paper proposes the definition of fractional definite integral and analyses the corresponding fundamental theorem of fractional calculus. In this context, we studied the relevant properties of the fractional derivatives that lead to such a definition.
Manuel Ortigueira, José Machado
doaj   +1 more source

The Generalized Fractional Calculus of Variations

open access: yes, 2014
We review the recent generalized fractional calculus of variations. We consider variational problems containing generalized fractional integrals and derivatives and study them using indirect methods.
Odzijewicz, Tatiana   +1 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Fractional Representation Formulae Under Initial Conditions and Fractional Ostrowski Type Inequalities

open access: yesDemonstratio Mathematica, 2015
Here we present very general fractional representation formulae for a function in terms of the fractional Riemann-Liouville integrals of different orders of the function and its ordinary derivatives under initial conditions.
Anastassiou George A.
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Fractional Derivatives, Fractional Integrals, and Fractional Differential Equations in Matlab

open access: yes, 2011
The term fractional calculus is more than 300 years old. It is a generalization of the ordinary differentiation and integration to non-integer (arbitrary) order. The subject is as old as the calculus of differentiation and goes back to times when Leibniz, Gauss, and Newton invented this kind of calculation.
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

On Improved Simpson-Type Inequalities via Convexity and Generalized Fractional Operators

open access: yesJournal of Mathematics
In this work, we develop novel Simpson-type inequalities for mappings with convex properties by employing operators for tempered fractional integrals. These findings expand upon and refine classical results, including those linked to Riemann–Liouville ...
Areej A. Almoneef   +3 more
doaj   +1 more source

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