Results 121 to 130 of about 1,811 (235)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some Fractional Integral and Derivative Formulas Revisited

Mathematics
In the most common literature about fractional calculus, we find that Dtαaft=It−αaft is assumed implicitly in the tables of fractional integrals and derivatives. However, this is not straightforward from the definitions of Itαaft and Dtαaft. In this sense, we prove that Dt0ft=It−α0ft is true for ft=tν−1logt, and ft=eλt, despite the fact that these ...
Juan Luis González-Santander, Francesco Mainardi   +1 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Framework for Derivative Pricing in the Fractional Black-Scholes Market [PDF]

The aim of this paper is to develop a framework for evaluating derivatives if the underlying of the derivative contract is supposed to be driven by a fractional Brownian motion with Hurst parameter greater than 0.5.
Ciprian Necula
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Recent applications of fractional calculus to science and engineering

International Journal of Mathematics and Mathematical Sciences, 2003
This paper deals with recent applications of fractional calculus to dynamical systems in control theory, electrical circuits with fractance, generalized voltage divider, viscoelasticity, fractional-order multipoles in electromagnetism, electrochemistry ...
Lokenath Debnath
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Editorial for the Special Issue of Mathematics “Fractional Differential Equations, Inclusions and Inequalities with Applications II”

Mathematics
Within the field of fractional calculus, defined fractional derivatives and integrals within complex domains and their practical applications are frequently explored, and in recent years, this field has seen a significant rise in research interest [...]
Sotiris K. Ntouyas
doaj   +1 more source

Feng’s First Integral Method Applied to the ZKBBM and the Generalized Fisher Space-Time Fractional Equations

Journal of Applied Mathematics, 2015
The fractional derivatives in the sense of the modified Riemann-Liouville derivative and Feng’s first integral method are employed to obtain the exact solutions of the nonlinear space-time fractional ZKBBM equation and the nonlinear space-time fractional
Huitzilin Yépez-Martínez, Ivan O. Sosa, Juan M. Reyes   +2 more
doaj   +1 more source

Fractional Derivatives, Fractional Integrals, and Fractional Differential Equations in Matlab

, 2011
The term fractional calculus is more than 300 years old. It is a generalization of the ordinary differentiation and integration to non-integer (arbitrary) order. The subject is as old as the calculus of differentiation and goes back to times when Leibniz, Gauss, and Newton invented this kind of calculation.
openaire   +2 more sources