Results 111 to 120 of about 1,811 (235)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Extended Ostrowski Type Inequalities Involving Conformable Fractional Integrals

, 2022
The purpose of this work is to establish extended Ostrowski type inequalities involving conformable fractional integrals. We first give an identity for functions whose ??fractional derivatives are bounded.
Bolu, Pınar, Erden, Samet
core   +1 more source

Advances in Fractional Modeling and Computation

Fractal and Fractional
Fractional calculus, the study of derivatives and integrals of arbitrary order [...]
Yuri Dimitrov, Slavi Georgiev, Venelin Todorov, Jordan Hristov   +3 more
doaj   +1 more source

On a Generic Fractional Derivative Associated with the Riemann–Liouville Fractional Integral

Axioms
In this paper, a generic fractional derivative is defined as a set of the linear operators left-inverse to the Riemann–Liouville fractional integral. Then, the theory of the left-invertible operators developed by Przeworska-Rolewicz is applied to deduce its properties.
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ON GENERALIZED FRACTIONAL INTEGRALS AND DERIVATIVES

, 2011
In this paper we present a generalization to two existing fractional integrals and derivatives, namely, the Riemann-Liouville and Hadamard fractional operators.
Katugampola, Don Udita Nalin
core   +1 more source

On Improved Simpson-Type Inequalities via Convexity and Generalized Fractional Operators

Journal of Mathematics
In this work, we develop novel Simpson-type inequalities for mappings with convex properties by employing operators for tempered fractional integrals. These findings expand upon and refine classical results, including those linked to Riemann–Liouville ...
Areej A. Almoneef, Abd-Allah Hyder, Fatih Hezenci, Hüseyin Budak   +3 more
doaj   +1 more source

Novel Ostrowski–Type Inequalities for Generalized Fractional Integrals and Diverse Function Classes [PDF]

In this work, novel Ostrowski-type inequalities for dissimilar function classes and generalized fractional integrals (FITs) are presented. We provide a useful identity for differentiable functions under FITs, which results in special expressions for ...
Hüseyin Budak, Hyder, Abd-Allah, Barakat, Mohamed A., Almoneef, Areej A., Budak, Huseyin, Mohamed A. Barakat, Areej A. Almoneef, Abd-Allah Hyder   +7 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source