Results 111 to 120 of about 2,428 (290)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Advances in Fractional Modeling and Computation

Fractal and Fractional
Fractional calculus, the study of derivatives and integrals of arbitrary order [...]
Yuri Dimitrov, Slavi Georgiev, Venelin Todorov, Jordan Hristov   +3 more
doaj   +1 more source

On a Generic Fractional Derivative Associated with the Riemann–Liouville Fractional Integral

Axioms
In this paper, a generic fractional derivative is defined as a set of the linear operators left-inverse to the Riemann–Liouville fractional integral. Then, the theory of the left-invertible operators developed by Przeworska-Rolewicz is applied to deduce its properties.
openaire   +2 more sources

Approximations for Fractional Derivatives and Fractional Integrals Using Padé Approximation

Journal of Applied Mathematics
This paper tackles the persistent challenge of slow convergence and numerical instability in the fractional calculus when applied to power series–representable functions , limitations that compromise accuracy in scientific applications. A novel reformulation of fractional derivatives and integrals is achieved by applying Padé approximation to ...
Ahmed M. Youssef, Tamer M. Rageh, Aisha F. Fareed, M. S. Abdelwahed   +3 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Framework for Derivative Pricing in the Fractional Black-Scholes Market [PDF]

The aim of this paper is to develop a framework for evaluating derivatives if the underlying of the derivative contract is supposed to be driven by a fractional Brownian motion with Hurst parameter greater than 0.5.
Ciprian Necula
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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

On Improved Simpson-Type Inequalities via Convexity and Generalized Fractional Operators

Journal of Mathematics
In this work, we develop novel Simpson-type inequalities for mappings with convex properties by employing operators for tempered fractional integrals. These findings expand upon and refine classical results, including those linked to Riemann–Liouville ...
Areej A. Almoneef, Abd-Allah Hyder, Fatih Hezenci, Hüseyin Budak   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Extended Ostrowski Type Inequalities Involving Conformable Fractional Integrals

, 2022
The purpose of this work is to establish extended Ostrowski type inequalities involving conformable fractional integrals. We first give an identity for functions whose ??fractional derivatives are bounded.
Bolu, Pınar, Erden, Samet
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