Results 91 to 100 of about 2,240 (300)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Stability of Non-standard Finite Difference Scheme for Solution of Partial Differential Equations of Fractional Order

پژوهش‌های ریاضی, 2015
Fractional derivatives and integrals are new concepts of derivatives and integrals of arbitrary order. Partial differential equations whose derivatives can be of fractional order are called fractional partial differential equations (FPDEs).
M. Arab Ameri, E Mir Mehrabi
doaj  

Fractional Representation Formulae Under Initial Conditions and Fractional Ostrowski Type Inequalities

Demonstratio Mathematica, 2015
Here we present very general fractional representation formulae for a function in terms of the fractional Riemann-Liouville integrals of different orders of the function and its ordinary derivatives under initial conditions.
Anastassiou George A.
doaj   +1 more source

Hadamard functional fractional integrals and derivatives and fractional differential equations

Filomat
This paper introduces a general type of new version of Hadamard fractional integrals and derivatives with respect to another function and studies some of their properties. Further, we prove the existence results for fractional differential equations with this Hadamard type fractional derivative.
K. Balachandran, M. Matar, N. Annapoorani, D. Prabu   +3 more
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Advances in Fractional Modeling and Computation

Fractal and Fractional
Fractional calculus, the study of derivatives and integrals of arbitrary order [...]
Yuri Dimitrov, Slavi Georgiev, Venelin Todorov, Jordan Hristov   +3 more
doaj   +1 more source

Lateral Trajectory Tracking of Self-Driving Vehicles Based on Sliding Mode and Fractional-Order Proportional-Integral-Derivative Control [PDF]

, 2023
Xiqing Zhang, Jin Li, Zhiguang Ma, Dianmin Chen, Xiaoxu Zhou   +4 more
openalex   +1 more source

Fractional Derivatives, Fractional Integrals, and Fractional Differential Equations in Matlab

, 2011
The term fractional calculus is more than 300 years old. It is a generalization of the ordinary differentiation and integration to non-integer (arbitrary) order. The subject is as old as the calculus of differentiation and goes back to times when Leibniz, Gauss, and Newton invented this kind of calculation.
openaire   +3 more sources