Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
On Improved Simpson-Type Inequalities via Convexity and Generalized Fractional Operators
Journal of MathematicsIn this work, we develop novel Simpson-type inequalities for mappings with convex properties by employing operators for tempered fractional integrals. These findings expand upon and refine classical results, including those linked to Riemann–Liouville ...
Areej A. Almoneef +3 more
doaj +1 more source
On refined Hardy-type inequalities with fractional integrals and fractional derivatives
Mathematica Slovaca, 2014 Abstract The aim of this paper is to present new more general Hardy-type inequalities for different kinds of fractional integrals and fractional derivatives.
Iqbal, Sajid +2 more
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Nonlinear Caputo Fractional Derivative with Nonlocal Riemann-Liouville Fractional Integral Condition Via Fixed Point Theorems [PDF]
, 2019 Piyachat Borisut +3 more
openalex +1 more source
Nonlinear regularized long-wave models with a new integral transformation applied to the fractional derivative with power and Mittag-Leffler kernel [PDF]
, 2020 Mehmet Yavuz, Thabet Abdeljawad
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A boundary problem with integral gluing condition for a parabolic-hyperbolic equation involving the Caputo fractional derivative [PDF]
, 2013 Erkinjon Karimov, J. S. Akhatov
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