Results 91 to 100 of about 537,797 (362)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Global Existence and Uniqueness of Solution of Atangana–Baleanu Caputo Fractional Differential Equation with Nonlinear Term and Approximate Solutions

International Journal of Differential Equations, 2021
In this paper, a class of fractional order differential equation expressed with Atangana–Baleanu Caputo derivative with nonlinear term is discussed.
Meryeme Hassouna, El Hassan El Kinani, Abdelaziz Ouhadan   +2 more
doaj   +1 more source

Boundary value problems for fractional differential equation with causal operators

, 2016
In this paper, we study the two-point boundary value problems for fractional differential equation with causal operator. By lower and upper solution method and the monotone iterative technique, some results for the extremal solution and quasisolutions ...
Jingfei Jiang, D. Cao, Huatao Chen
semanticscholar   +1 more source

On Analytical Solutions of the Fractional Differential Equation with Uncertainty: Application to the Basset Problem

Entropy, 2015
In this paper, we apply the concept of Caputo’s H-differentiability, constructed based on the generalized Hukuhara difference, to solve the fuzzy fractional differential equation (FFDE) with uncertainty. This is in contrast to conventional solutions that
S. Salahshour, A. Ahmadian, N. Senu, D. Baleanu, P. Agarwal   +4 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Fractional Fourier Transform and Ulam Stability of Fractional Differential Equation with Fractional Caputo-Type Derivative

Journal of Function Spaces, 2022
In this paper, we study the Ulam-Hyers-Mittag-Leffler stability for a linear fractional order differential equation with a fractional Caputo-type derivative using the fractional Fourier transform.
Arunachalam Selvam, Sriramulu Sabarinathan, Samad Noeiaghdam, Vediyappan Govindan   +3 more
doaj   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Existence, Uniqueness and Stability Theorems for Certain Functional Fractional Initial Value Problem [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2011
In this paper, we deal with non-linear  functional fractional differential  equation  with initial condition in  space. We will study the existence, uniqueness and stability of the solution of  fractional differential equation.
Joseph Abulahad, Shayma Murad
doaj   +1 more source

Singular fractional differential equations [PDF]

PAMM, 2013
AbstractFractional differential equations have received increasing attention during recent years since the behavior of many physical systems can be properly described using the fractional order system theory.By fractional analog for Duhamel principle we give the existence‐uniqueness result for linear and nonlinear time fractional evolution equations ...
openaire   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source