Results 71 to 80 of about 17,486 (265)

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

A Domain Decomposition Method for Time Fractional Reaction-Diffusion Equation

open access: yesThe Scientific World Journal, 2014
The computational complexity of one-dimensional time fractional reaction-diffusion equation is O(N2M) compared with O(NM) for classical integer reaction-diffusion equation. Parallel computing is used to overcome this challenge.
Chunye Gong   +4 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Solutions of certain fractional kinetic equations and a fractional diffusion equation [PDF]

open access: yesJournal of Mathematical Physics, 2010
In view of the usefulness and importance of kinetic equations in certain physical problems, the authors derive an explicit solution of a fractional kinetic equation of general character that unifies and extends earlier results. Further, an alternative shorter method based on a result developed by the authors is given to derive the solution of a ...
Saxena, R. K.   +2 more
openaire   +3 more sources

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo   +9 more
wiley   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

open access: yesArthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet   +11 more
wiley   +1 more source

Cauchy problem for fractional diffusion equations

open access: yesJournal of Differential Equations, 2004
Version 2 contains a correction (formula 4.14) as compared with the published ...
Eidelman, Samuil D.   +1 more
openaire   +2 more sources

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

open access: yesArthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci   +25 more
wiley   +1 more source

The Inverse Nodal problem for the fractional diffusion equation

open access: yesActa Scientiarum: Technology, 2015
In this paper, on a general finite interval, the inverse problem of recovering the potential function for a fractional diffusion equation with new spectral parameter, called the nodal point, is given.
Erdal Bas
doaj   +1 more source

Time Fractional Fisher–KPP and Fitzhugh–Nagumo Equations

open access: yesEntropy, 2020
A standard reaction–diffusion equation consists of two additive terms, a diffusion term and a reaction rate term. The latter term is obtained directly from a reaction rate equation which is itself derived from known reaction kinetics, together with ...
Christopher N. Angstmann, Bruce I. Henry
doaj   +1 more source

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