Results 81 to 90 of about 17,442 (284)

Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Injectable pH responsive conductive hydrogel for intelligent delivery of metformin and exosomes to alleviate myocardial ischemia‐reperfusion injury. The hydrogel responds to the weakly acidic microenvironment of ischemic injury and can significantly reduce the production of intracellular ROS and enhance cardiac conduction, thereby resisting apoptosis ...
Nianlan Cheng, Qiao Luo, Yongqing Yang, Ni Shao, Tianqi Nie, Xiujiao Deng, Jifeng Chen, Siqi Zhang, Yanyu Huang, Kuan Hu, Liangping Luo, Zeyu Xiao   +11 more
wiley   +1 more source

Diagnostic accuracy of myocardial perfusion imaging with czt technology. Systemic review and meta-analysis of comparison with invasive coronary angiography [PDF]

, 2017
OBJECTIVES: This study sought to summarize the evidence on stress myocardial perfusion imaging (MPI) using cadmium-zinc-telluride (CZT) technology for the diagnosis of obstructive coronary artery disease (CAD). The CZT cameras are newly introduced, and
Biondi-Zoccai, Giuseppe, Frati, Giacomo, Iskandrian, Ami E., Nudi, Francesco, Peruzzi, Mariangela, Schillaci, Orazio   +5 more
core   +2 more sources

Application of pressure-derived myocardial fractional flow reserve in chronic hemodialysis patients [PDF]

Journal of Cardiology, 2018
Although fractional flow reserve (FFR) measurements during coronary angiography are performed in routine clinical practice, few studies have evaluated FFR measurements in dialysis patients.We retrospectively studied 42 hemodialysis patients with suspected or known coronary artery disease (CAD) who underwent stress myocardial perfusion imaging and ...
Taishiro Chikamori, Satoshi Hida, Tetsushi Saitoh, Jun Yamashita, Hirokazu Tanaka, K. Hirose, Yuko Igarashi, Akira Yamashina, Nobuhiro Tanaka   +8 more
openaire   +3 more sources

Stress Myocardial Perfusion Imaging Interpretation From the Viewpoint of Fractional Flow Reserve

Circulation Journal, 2021
Myocardial perfusion imaging (MPI) and fractional flow reserve (FFR) are established approaches to the assessment of myocardial ischemia. Recently, various FFR cutoff values were proposed, but the diagnostic accuracy of MPI in identifying positive FFR using various cutoff values is not well established.Methods and Results:We retrospectively studied 273
Itta Kawamura, Hideaki Ota, Hiroyuki Omori, Yoshiaki Kawase, Kunihiko Tsuchiya, Yoshihiro Sobue, Masayasu Nakagawa, Takuya Mizukami, Hiroki Kamiya, Toru Tanigaki, Jun Kikuchi, Takeshi Kondo, Takahiko Suzuki, Tetsuo Hirata, Munenori Okubo, Taiji Miyake, Masanori Kawasaki, Hitoshi Matsuo   +17 more
openaire   +4 more sources

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Case Report: Dual-Energy Computed Tomography of Cardiac Changes in IgG4-Related Disease

Frontiers in Cardiovascular Medicine, 2022
BackgroundDual-energy computed tomography (DECT) is used in coronary plaque characterization, myocardial perfusion imaging, and pulmonary embolism diagnosis; however, there is no relevant research on DECT in IgG4-related diseases (IgG4-RD) involving the ...
Ying Wang, Ying Wang, Hui Zhou, Hui Zhou, Ping Hu, Ping Hu, Jie Zhao, Jie Zhao, Yitao Mao, Yitao Mao, Zhixiao Li, Zhixiao Li, Xi Zhao   +12 more
doaj   +1 more source

Repeatability of fractional flow reserve despite variations in systemic and coronary hemodynamics [PDF]

, 2015
Objectives This study classified and quantified the variation in fractional flow reserve (FFR) due to fluctuations in systemic and coronary hemodynamics during intravenous adenosine infusion.
Berry, C., De Bruyne, B., Fearon, W.F., Gould, K.L., Johnson, D.T., Johnson, N.P., Kirkeeide, R.L., Oldroyd, K.G., Pijls, N.H.J.   +8 more
core   +2 more sources

Fractional flow reserve and myocardial perfusion by computed tomography: a guide to clinical application [PDF]

European Heart Journal - Cardiovascular Imaging, 2017
The aim of this paper is to provide a guide to the clinical application of the functional computed tomography (CT) techniques fractional flow reserve (CT FFR) and myocardial perfusion (CTP) in patients presenting for the evaluation of coronary artery disease (CAD). Both techniques have recently been introduced to complement coronary CT angiography (CTA)
Joanne D. Schuijf, Brian Ko, Sujith Seneviratne, Jacqueline Hislop-Jambrich, Joao A.C. Lima, Marcelo F. Di Carli, Abdul Rahman Ihdayhid   +6 more
openaire   +3 more sources

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source