Results 71 to 80 of about 60,780 (302)

Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The impact of sex‐related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. Methods and Results This is a secondary analysis of patients with stable coronary artery disease who ...
Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen   +8 more
doaj   +1 more source

Impact of incomplete ventricular coverage on diagnostic performance of myocardial perfusion imaging. [PDF]

, 2017
In the context of myocardial perfusion imaging (MPI) with cardiac magnetic resonance (CMR), there is ongoing debate on the merits of using technically complex acquisition methods to achieve whole-heart spatial coverage, rather than conventional 3-slice ...
Arsanjani, Reza, Berman, Daniel S, Dharmakumar, Rohan, Fish, Mathews B, Germano, Guido, Li, Debiao, Motwani, Manish, Sharif, Behzad, Slomka, Piotr   +8 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Implementation of ultrasonic sensing for high resolution measurement of binary gas mixture fractions [PDF]

, 2014
We describe an ultrasonic instrument for continuous real-time analysis of the fractional mixture of a binary gas system. The instrument is particularly well suited to measurement of leaks of a high molecular weight gas into a system that is nominally ...
Bates, Richard, Battistin, Michele, Berry, Stephane, Bitadze, Alexander, Bonneau, Pierre, Bousson, Nicolas, Boyd, George, Bozza, Gennaro, Brookhaven National Lab. (BNL), Upton, NY (United States), Crespo-Lopez, Olivier, Da Riva, Enrico, Degeorge, Cyril, Deterre, Cecile, DiGirolamo, Beniamino, Doubek, Martin, Favre, Gilles, Godlewski, Jan, Hallewell, Gregory, Hasib, Ahmed, Katunin, Sergey, Langevin, Nicolas, Lombard, David, Lombard, Didier, Mathieu, Michel, McMahon, Stephen, Nagai, Koichi, Pearson, Benjamin, Robinson, David, Rossi, Cecilia, Rozanov, Alexandre, Strauss, Michael, Vacek, Vaclav, Vitek, Michal, Zwalinski, Lukasz   +33 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Functional assessment of coronary stenosis: alternative hyperemic, nonhyperemic, and angiographic indexes

REC: Interventional Cardiology (English Ed.)
Assessment of the functional significance of coronary artery stenoses to guide percutaneous coronary intervention is widely performed using pressure wire fractional flow reserve during adenosine- or adenosine triphosphate-induced hyperemia.
Federico Vergni, Giuliano Fiore, Francesco Pellone, Mario Luzi   +3 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Developing precision stroke imaging. [PDF]

, 2014
Stroke experts stand at the cusp of a unique opportunity to advance the care of patients with cerebrovascular disorders across the globe through improved imaging approaches.
Feldmann, Edward, Liebeskind, David S
core   +2 more sources

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source

Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study [PDF]

, 2017
Background: Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in patients with diabetes. Methods:
Adjedj, Julien, Barbato, Emanuele, Esposito, Giovanni, Fearon, William, Ferrone, Marco, Gargiulo, Giuseppe, Hennigan, Barry, Jeremias, Allen, Johnson, Nils, Matsumura, Mitsuaki, On behalf of the CONTRST Study Investigators, Stabile, Eugenio, Trimarco, Bruno, Zimmermann, Frederik   +13 more
core   +2 more sources