Results 101 to 110 of about 1,618,914 (306)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Certain Inequalities Involving Generalized Erdélyi-Kober Fractional q-Integral Operators

The Scientific World Journal, 2014
In recent years, a remarkably large number of inequalities involving the fractional q-integral operators have been investigated in the literature by many authors.
Praveen Agarwal, Soheil Salahshour, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source

Some new inequalities for generalized fractional conformable integral operators

Advances in Difference Equations, 2019
The present paper aims to establish certain new classes of integral inequalities for a class of n ( n∈N $n\in \mathbb{N}$) positive continuous and decreasing functions by utilizing the generalized fractional conformable integral operators (FCIO) recently
Kottakkaran Sooppy Nisar, Gauhar Rahman, Aftab Khan   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

New Modified Conformable Fractional Integral Inequalities of Hermite–Hadamard Type with Applications

, 2020
In this study, a few inequalities of Hermite–Hadamard type are constructed via the conformable fractional operators so that the normal version is recovered in its limit for the conformable fractional parameter.
T. Abdeljawad, P. Mohammed, A. Kashuri
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Some results on quantum Hahn integral inequalities

Journal of Inequalities and Applications, 2019
In this paper the quantum Hahn difference operator and the quantum Hahn integral operator are defined via the quantum shift operator Φqθ(t)=qt+(1−q)θ $_{\theta }\varPhi _{q}(t)=qt+(1-q)\theta $, t∈[a,b] $t\in [a,b]$, θ=ω/(1−q)+a $\theta = \omega /(1-q)+a$
Suphawat Asawasamrit, Chayapat Sudprasert, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source

Inequalities by Means of Generalized Proportional Fractional Integral Operators with Respect to Another Function

, 2019
In this article, we define a new fractional technique which is known as generalized proportional fractional (GPF) integral in the sense of another function Ψ .
S. Rashid, F. Jarad, M. Noor, H. Kalsoom, Y. Chu   +4 more
semanticscholar   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source