Results 51 to 60 of about 225,962 (269)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Picard and Adomian decomposition methods for a fractional quadratic integral equation via generalized fractional integral

Iraqi Journal for Computer Science and Mathematics
 The primary focus of this paper is to thoroughly examine and analyze a class of a fractional quadratic integral equation via generalized fractional integral.
Alan Jalal Abdulqader, Saleh S. Redhwan, Ali Hasan Ali, Omar Bazighifan, Awad T. Alabdala   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

New Inequalities Using Multiple Erdélyi–Kober Fractional Integral Operators

Fractal and Fractional
The role of fractional integral inequalities is vital in fractional calculus to develop new models and techniques in the most trending sciences. Taking motivation from this fact, we use multiple Erdélyi–Kober (M-E-K) fractional integral operators to ...
Asifa Tassaddiq, Rekha Srivastava, Rabab Alharbi, Ruhaila Md Kasmani, Sania Qureshi   +4 more
doaj   +1 more source

Generalized Fractional Hadamard and Fejér–Hadamard Inequalities for Generalized Harmonically Convex Functions

Journal of Mathematics, 2020
In this paper, we define a new function, namely, harmonically α,h−m-convex function, which unifies various kinds of harmonically convex functions.
Chahn Yong Jung, Muhammad Yussouf, Yu-Ming Chu, Ghulam Farid, Shin Min Kang   +4 more
doaj   +1 more source

On the weighted fractional integral inequalities for Chebyshev functionals

Advances in Difference Equations, 2021
The goal of this present paper is to study some new inequalities for a class of differentiable functions connected with Chebyshev’s functionals by utilizing a fractional generalized weighted fractional integral involving another function G $\mathcal{G ...
Gauhar Rahman, Kottakkaran Sooppy Nisar, Sami Ullah Khan, Dumitru Baleanu, V. Vijayakumar   +4 more
doaj   +1 more source

Elements of fractional calculus. Fractional integrals

Bulletin of Taras Shevchenko National University of Kyiv. Series: Physics and Mathematics, 2022
The paper is devoted to the basic properties of fractional integrals. It is a survey of the well-known properties of fractional integrals, however, the authors tried to present the known information about fractional integrals as short and transparently as possible. We introduce fractional integrals on the compact interval and on the semi-axes, consider
Yuliya Mishura, Olha Hopkalo, Hanna Zhelezniak   +2 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source