Results 61 to 70 of about 234,622 (320)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

On fractional Bullen-type inequalities with applications

open access: yesAIMS Mathematics
Integral inequalities in mathematical interpretations are a substantial and ongoing body of research. Because fractional calculus techniques are widely used in science, a lot of research has recently been done on them.
Sobia Rafeeq, Sabir Hussain, Jongsuk Ro
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Generalized Fractional Hadamard and Fejér–Hadamard Inequalities for Generalized Harmonically Convex Functions

open access: yesJournal of Mathematics, 2020
In this paper, we define a new function, namely, harmonically α,h−m-convex function, which unifies various kinds of harmonically convex functions.
Chahn Yong Jung   +4 more
doaj   +1 more source

New extensions of Chebyshev-Pólya-Szegö type inequalities via conformable integrals

open access: yesAIMS Mathematics, 2020
Recently, several papers related to integral inequalities involving various fractional integral operators have been presented. In this work, motivated essentially by the previous works, we prove some new Polya-Szegö inequalities via conformable ...
Erhan Deniz   +2 more
doaj   +1 more source

Fractional Integral Operators

open access: yes, 2023
equipped with a positive Radon measure .
openaire   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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