Results 81 to 90 of about 225,962 (269)

Some new inequalities for generalized fractional conformable integral operators

Advances in Difference Equations, 2019
The present paper aims to establish certain new classes of integral inequalities for a class of n ( n∈N $n\in \mathbb{N}$) positive continuous and decreasing functions by utilizing the generalized fractional conformable integral operators (FCIO) recently
Kottakkaran Sooppy Nisar, Gauhar Rahman, Aftab Khan   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Fractional Integral Inequalities of Gruss Type via Generalized Mittag-Leffler Function

International Journal of Analysis and Applications, 2019
We use generalized fractional integral operator containing the generalized Mittag-Leffler function to establish some new integral inequalities of Gr¨uss type. A cluster of fractional integral inequalities have been identified by setting particular values
G. Farid, A. U. Rehman, Vishnu Narayan Mishra, S. Mehmood   +3 more
doaj   +2 more sources

Weak Type Inequalities for Some Integral Operators on Generalized Nonhomogeneous Morrey Spaces

Journal of Function Spaces and Applications, 2013
We prove weak type inequalities for some integral operators, especially generalized fractional integral operators, on generalized Morrey spaces of nonhomogeneous type.
Hendra Gunawan, Denny Ivanal Hakim, Yoshihiro Sawano, Idha Sihwaningrum   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Numerical solution of fractional boundary value problem with caputo-fabrizio and its fractional integral. [PDF]

J Appl Math Comput, 2022
Moumen Bekkouche M, Mansouri I, Ahmed AAA.   +2 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Certain Results Comprising the Weighted Chebyshev Function Using Pathway Fractional Integrals

Mathematics, 2019
An analogous version of Chebyshev inequality, associated with the weighted function, has been established using the pathway fractional integral operators. The result is a generalization of the Chebyshev inequality in fractional integral operators.
Aditya Mani Mishra, Dumitru Baleanu, Fairouz Tchier, Sunil Dutt Purohit   +3 more
doaj   +1 more source